【作者】 周忠凯；

【导师】 葛家璞；

【作者基本信息】 新疆医科大学 ， 内科学， 2010， 硕士

【摘要】 目的:研究盐酸吡格列酮(PIG)对2型糖尿病患者血脂、血清超敏C-反应蛋(hs-CRP)、尿白蛋白排泄率、骨密度的影响。方法:选取于2009年3月至2010年1月在我院就诊血糖控制不佳的2型糖尿病患者50例,给予口服PIG治疗12周;检测患者治疗前后的身高、体重、血压、空腹血糖(FPG)、空腹胰岛素(FINS)、血脂谱、hs-CRP、尿白蛋白排泄率(UAER)、骨密度(BMD);计算体重指数(BMI)、胰岛素抵抗指数(HOMA-IR)。对测量数据行t检验或者秩和检验进行分析。结果:1.PIG治疗后FPG、FINS、HOMA-IR、甘油三酯、hs- CRP、UAER较治疗前下降(P<0.05);2.高密度脂蛋白胆固醇较前升高(P <0.05);3.其余BMI、血压、总胆固醇、低密度脂蛋白、脂蛋白(a)、骨密度无显著变化。结论:应用PIG在改善胰岛素抵抗、降低血糖的同时可调节血脂、降低hs-CRP、减少尿微量白蛋白,从而延缓糖尿病及糖尿病肾病的发生和发展。短期内使用PIG对骨密度无明显影响。更多还原

【Abstract】 Objective: To observe the effects of pioglitazone (PIG) on blood lipids , high sensitive C-reactive protein (hs-CRP), urine albumin excretory rate (UAER) ,and bone mineral density (BMD) in patients with type 2 diabetes mellitus(T2DM). Methods: Fifty T2DM patients with poorly controlled blood glucose were given PIG for 12 weeks in our hospital between March 2009 and January 2010; The changes of of body height, body weight, blo- od pressure, fasting blood glucose (FPG), fasting insulin (FINS), blood lipids, hs-CRP , UAER , and BMD were measured in patients at the baseline and 12weeks after the therapy. Homeostasis model assessment indexes (HOMA-IR) was calculated by the HOMA model. Body mass index (BMI) was also calculated. For all data, t test or Rank sum test were con- duct. Results:1.There was a significant decrease in FPG,FINS,HOMA-IR, triglyceride (T G), hs-CRP and UAER (P < 0.05) after PIG treatment for 12 weeks; 2. The high-density lioprotein-cholesterol (HDL-C) level increased compared to the baseline (P <0.05). 3. However ,there was no signficant difference in BMI, blood pressure, totalcholesterol (TC) , low-density lioprotein-cholesterol (LDL-C), Lp(a),BMD(P >0.05). Conclusion: The treatment of PIG can not only improve insulin sensitivity but also decrease the level of hs-CRP and UREA. PIG can prevent the development of diabetes melleius and diabetic nephropathy. PIG has no impact on BMD during the treatment in short time.更多还原