【作者】 张颖；

【导师】 林雪；

【作者基本信息】 新疆医科大学 ， 中西医结合临床， 2010， 硕士

【摘要】 目的:运用虚燥更平方治疗女性高血压病(更年期)阴虚内燥证患者,观察其神经内分泌免疫各相关指标治疗前后的变化,探讨虚燥更平方对神经内分泌免疫网络的影响。方法:选取2008年12月至2009年7月新疆维吾尔自治区中医院高血压科就诊的63例女性高血压病(更年期)阴虚内燥证患者随机分成治疗组30例和对照组33例,两组分别给药6周并于治疗前后进行诊室血压,神经肽Y,神经降压素,β-内啡肽,性激素指标的检测,并做统计分析比较。结果: (1)与对照组比较,治疗组患者治疗后诊室血压减小,但两组比较无统计学意义(P>0.05);治疗组患者血浆NPY水平较治疗前降低,有统计学意义(P<0.05),NT、β-EP无统计学意义(P>0.05);治疗组患者治疗后血清E2水平升高, T、FSH水平降低,三者有统计学意义(P<0.05),P、PRL、LH无统计学意义(P>0.05);(2)亚组分析:与1级高血压病对照组比较,治疗组患者血浆NPY、NT、β-EP水平均无统计学意义(P>0.05);与2级高血压对照组比较,治疗组患者血浆NPY水平较治疗前降低,β-EP水平较治疗前升高,两者有统计学意义(P<0.05),NT无统计学意义(P>0.05);(3)亚组分析:与绝经前对照组比较,治疗组患者治疗后血清E2水平升高, FSH水平降低,两者有统计学意义(P<0.05),其余性激素无统计学意义;与绝经后对照组比较,治疗组患者治疗后血清T、LH水平降低,两者有统计学意义(P<0.05),其余性激素无统计学意义。结论:(1)运用虚燥更平方治疗对改善女性高血压病(更年期)阴虚内燥证患者神经-内分泌-免疫网络具有一定的调节作用。(2)通过治疗前后神经内分泌免疫各相关指标水平的变化说明女性高血压病(更年期)阴虚内燥证患者紊乱的神经-内分泌-免疫功能与高血压病的发生、发展关系密切。更多还原

【Abstract】 Objective: To study the clinical efficacy of Xu-zao-geng-ping-prescription on the female climacteric hypertension patients and analyzes their Nero-immunoendocrinology index. Method: 63 female climacteric hypertension patients from Dec 2008 to Jul 2009 were collected and divided into treatment group and control group, compared with two group indexes of OBP, NPY, NT,β-EP and Sex hormones before treatment and after treatment 6 weeks. Results: (1) Compared with control group, after treatment no differences were found on OBP (P>0.05), but NPY, T, FSH, E2 were difference in two groups. In the treatment group, the level of E2 was obviously rise and its NPY, T, FSH were significantly lower than control group (both P<0.05). (2) Compared with control group, no differences were found on indexes after treatment between two group in grade 1 hypertension (both P>0.05). In the treatment group, the level ofβ-EP was increased and its NPY was obviously decreased than control group after treatment in grade 2 hypertension (both P<0.05). (3) Compared with control group, the treatment group level of E2 was increased and its FSH was decreased in pre-menopause hypertension (both P<0.05) and the levels of T, LH were lower than control group in post-menopause after treatment. (both P<0.05). Conclusion: Xu-zao-geng-ping-prescription can treat menopausal hypertension in female through raise E2,β-EP and lower NPY,T, FSH levels and disorder Nero-immunoendocrinology index may participate the patho-physiological course of menopausal hypertension in female.更多还原