【作者】 王琴；

【导师】 王爱国；

【作者基本信息】 湖北中医药大学 ， 中西医结合临床， 2010， 硕士

【摘要】 旨在观察疏肝活血方治疗肝郁气滞型黄褐斑的临床疗效,探索对黄褐斑安全、有效、方便的中药方剂及治疗方法,达到提高疗效、减少复发、改善临床伴随症状的目的,从而为此方在临床的广泛运用提供理论依据。所有病例均为2007年6月-2009年10月在湖北省中医院门诊治疗的肝郁气滞型黄褐斑患者,将45例黄褐斑患者随机分为治疗组和对照组,治疗组23例,男3例,女20例；年龄22-47岁,平均(30.7±4.2)岁；病程5月-11年,平均(7.0±2.8)年；其中皮损蝶形型9例,面上部型7例,面下部型6例,泛发型1例。对照组22例,男1例,女21例；年龄20-51岁,平均(32.8±3.9)岁；病程4月-13年,平均(8.1±3.7)年；其中皮损蝶形型8例,面上部型6例,面下部型6例,泛发型2例。两组患者在性别、年龄、病程、中医症型等方面差异无显著性(P＞0.05),具有可比性。治疗组23例,采用疏肝活血方中药治疗。对照组22例,给予维生素C、维生素E口服和迪维霜外用。两组治疗均2个月为1疗程,用药2个疗程后观察临床疗效。凡符合病例入选标准纳入试验的病例,进行分析比较,治疗前及治疗后的各项症状、体征。计数资料采用χ2检验,计量资料用t检验。两组临床疗效比较,经x2检验,治疗组疗效明显高于对照组(P＜0.01),疏肝活血方是治疗肝郁气滞型黄褐斑的有效方法之一。两组皮损面积治疗后积分比较,经t检验,治疗组和对照组有显著性差异(P＜0.05),疏肝活血方能显著降低肝郁气滞型黄褐斑皮损面积和颜色。两组皮损表现治疗后总积分比较,经t检验,治疗组和对照组有极显著性差异(P＜0.05),疏肝活血方能明显降低肝郁气滞型黄褐斑患者皮损表现总积分。疏肝活血方治疗组在疾病疗效及证侯疗效上均优于对照组。治疗前后检查血、尿、便常规及肝、肾功能均未见异常。说明疏肝活血方无明显毒副作用。疏肝活血方在疗效上明显优于西药,说明疏肝活血方治疗肝郁气滞型黄褐斑疗效显著,值得在临床上进一步应用探讨。更多还原

【Abstract】 The purpose was to observe the Treatment of Liver Blood liver Qi stagnation, the clinical effect of chloasma, melasma explore safe, effective and convenient method of Chinese medicine prescriptions and treatment, to improve efficacy and reduce recurrence, improve the clinical symptoms associated with the purpose of to this side to provide widely used in clinical theoretical。All cases were in June 2007-October 2009 in Hubei Province Chinese Medicine Hospital out-patient treatment melasma, the 45 cases of chloasma were randomly divided into treatment group and control group, treatment group 23 cases, three cases of men and women 20 cases; the age of 22-47 years old, on average (30.7±4.2) years of age; course in May to 11 years, the average (7.0±2.8) years; of which nine cases of type butterfly lesions, seven cases of type upper, lower surface type six cases, the Pan-one cases of hair.22 cases of the control group, one cases of male, female 21 cases; the age of 20 to 51 years old, on average (32.8 ±3.9) years of age; course in April to 13 years, the average (8.1±3.7) years; of which eight cases of lesions of butterfly type, six cases of upper-type, six cases of type bottom surface, two cases of pan-hair. Two groups in terms of gender, age, duration, severity, etc. There was no significant difference (P> 0.05), comparable.23 cases of treatment group, using traditional Chinese medicine treatment of liver Huoxue law, the control group given vitamin C, vitamin E cream for external use oral and Sedivy. Treatment groups for 1 on a course of treatment, drug treatment, observation of two clinical efficacy.Where standards into line with the test cases selected cases, the analysis compared before and after treatment of the symptoms and signs. Count data usingχ2 test.The treatment group compared with the control group effect, theχ2 test, efficacy of the treatment group was significantly higher than (P<0.01), liver Chloasma Huoxue is an effective treatment methods.Shugan Huoxue method was superior in terms of curative effects on western medicine on treatment of liver Huoxue Chloasma significant effect, it is worth further in the clinical application of.更多还原