【作者】 徐秋晶；

【导师】 万柏坤；

【作者基本信息】 天津大学 ， 生物医学工程， 2009， 硕士

【摘要】 视觉注意一直是心理学、神经生理学的重要研究领域,近年来随着脑功能探测技术的发展,对于视觉注意力的研究已经从早期的定性描述发展到利用各种神经生理学信号对大脑不同状态下的注意力水平进行定量化分析的阶段。目前,视觉注意力水平的定量化研究尚在选取表征注意力的特征参数与量化的分级方面存在一定的缺陷。寻找新的能客观准确地反映视觉注意力水平的特征参数,建立能稳定、可靠地监测并可动态调控操作者视觉注意力水平的生物反馈系统,将不仅有利于揭示人脑中视觉注意力的心理学、神经生理学方面的作用机制,还将有益于与注意力相关脑神经疾病的诊断和治疗,促进脑-机接口等神经工程新技术及在康复医学中的应用。本文设计了两种用于测试多级视觉注意力水平的脑电反馈实验,通过要求受试者注视屏幕动画并按照提示进行不同强度的想象动作过程并记录多个注意集中程度下的脑电数据。分别采用脑电信号的近似熵、样本熵、多尺度熵、δ-样本熵等基于序列复杂性测度的非线性动力学参数来表征受试者的视觉注意集中程度。经14名受试者实验及其脑电信号熵参数统计分析结果表明,在绝大多数额叶导联(F3、F4、F7、F8、Fz)和部分颞叶导联(T3、T4等)处的多个注意集中程度之间存在显著性差异,并且随受试者注意集中程度的降低,其熵值呈下降趋势;发现样本熵在区分多个注意集中程度时的敏感度最高。为实现多级注意力水平的量化分级,本文优化设计了支持向量机分类器,对注意力水平进行了分级识别,识别率达到85.24%,可以将多种注意力集中程度区分开。最后对受试者注意力集中程度与其想象动作电位特征之间的相关性进行了初步研究。以上基于脑电熵参数的视觉注意力分级研究方法和结果可为脑与认知神经科学基础研究、脑电生物反馈训练以及在线脑-机接口系统设计提供参考依据与技术支持。更多还原

【Abstract】 Research of visual attention is one of the important domains of psychology and neurophysiology. In recent years, with the development of brain function detecting technology, the research of visual attention has improved from the stage of qualitative analysis to that of quantitative analysis under different functional conditions by utilizing variety of neurophysiologic signals. However, there are still certain defects on the feature parameters selection and attention levels classification in this quantitative research. To seek new parameters which can reflect the levels of attention accurately and objectively, and to establish a stable and reliable biofeedback system to monitor and control the operator’s visual attention levels dynamically will not only be helpful in revealing the mechanism of visual attention in the psychology and neurophysiology field, but also could be useful to diagnose and treat the brain diseases related to the attention. In this way, it can promote new technology, such as brain-computer interface (BCI) etc, and application in neural and rehabilitation engineering.In this thesis, there were two electroencephalogram (EEG) feedback experiments to measure the different levels of visual attention. In these experiments, following flash stimulus displayed on the screen, all subjects were required to finish different imaginary motor tasks corresponding to multi attention levels and EEG was recorded for further research. In order to assess different visual attention levels, the next step was to process EEG data with nonlinear dynamics parameters based on sequence complexity, such as approximate entropy, sample entropy, multiscale entropy,δ- sample entropy. According to the statistics analysis of entropy parameters of EEG signals of 14 subjects, there are significant differences in attention intensity in most of the electrodes in the frontal regions, such as F3、F4、F7、F8、Fz, and some of the electrodes in temporal regions, such as T3, T4. The values of entropy show a declining tendency with the level of attention declining and sample entropy has the highest sensitivity when discriminating different levels of attention. To realize attention levels quantification, a classifier based on support vector machine was optimized and was used to recognize the levels of attention with recognition ratio of 85.24%. Thus, it can distinguish the different levels of attention. The last segment of this thesis is the analysis of relevance between attention levels and motor imaginary potentials. With the mentioned research methods and results above, it can supply the reference and technical support for the basic research in brain and cognition neuroscience, EEG biofeedback training system and BCI online system design.更多还原