【作者】 刘子美；

【导师】 高树迎；

【作者基本信息】 山东中医药大学 ， 中医儿科学， 2009， 硕士

【摘要】 目的:从理论、临床两方面对泻肺平喘合剂治疗喘憋性肺炎痰热闭肺证的疗效进行系统观察和研究,并探讨其作用机理,为小儿本病本证的医治寻求新方法、新途径。方法:将符合西医毛细支气管和中医肺炎喘嗽痰热闭肺证诊断标准的60例患儿,随机分为治疗组和对照组各30例。两组均在常规治疗的基础上,治疗组给予泻肺平喘合剂灌肠,对照组给予小儿咳喘灵冲剂口服,七天为一疗程。七天后观察两组临床疗效,同时进行对照比较。结果:临床研究显示,治疗组总有效率为96.7%,对照组总有效率为86.7%,治疗组疗效明显优于对照组(P<0.05)。在改善发热、咳嗽、喉间痰鸣、喘憋、肺部啰音、x线胸片异常、T细胞亚群等主要症状、体征、辅助检查方面以及住院时间方面治疗组均优于对照组(P<0.05)。两组在改善鼻煽、精神异常、小便异常方面比较P>0.05,无差异。两组在改善紫绀、咽赤、口渴、大便异常方面比较P<0.05,有差异,治疗组优于对照组。两组在白细胞计数异常改善方面无差异(P>0.05)。同时治疗组疗效与小儿年龄、病情、病程有关(P<0.05):即年龄愈小疗效越差,年龄愈大疗效越好;病情愈轻疗效越好,病情愈重疗效越差;病程愈短疗效越好,病程愈长疗效越差。临床安全性指标研究结果表明:泻肺平喘合剂对于重要脏器无毒副作用。结论:泻肺平喘合剂治疗喘憋性肺炎痰热闭肺证是安全有效的,值得临床推广和应用。更多还原

【Abstract】 Objective:By observing and investigating the curative effect of Xie Fei Ping Chuan Mixture on treating the disease of phlegm-heat obstracting lungs of children Bronchio1itis and its mechanisation through theory and clinic.We try to find a new method and way which can treat the disease of phlegm-heat obstracting lungs of children Bronchio1itis .Methods:According to the rule of stratified randomization, 60cases had been carefully chosen as study subjects according to the western medicine’s diagnostic criterion of children’s bronchiolitis and the TCM diagnostic criterion of accumulation of phlegm-heat syndrome of children’s bronchiolitis. According to the rule of randomization, all subjects were divided into two groups,the treatment group and control group,30 cases of each. Both groups were given the routine treatment, at the same time,The treatment group was given Xie Fei Ping Chuan Mixture enema.The control group was infused cough and asthma granule oral , seven days for power spirit a treatment. After seven days , The total curative effect of observation between two groups. Results: Clinical studies show that the total efficiency of the treatment group is 96.7%,and the total efficiency of the control group is 86.7%, It indicated the total efficiency of the treatment group was much better than of the control group(P < 0.05). Being compared with the control group,The treatment group in improving main symptoms, signs, auxiliary examination and hospitalization treatment such as fever, cough, asthma, sputum throat to suppress,auscultation on lung, the abnormal condition of chest x-ray, T lymphocyte subsets were superior to the control group (P < 0.05). There was no difference in improving the nose incites, the mental disorders, and the abnormal urine between two groups (P > 0.05). The difference between the treatment group and the control group in improving cyanosis , pharyngeal redness, thirsty, abnormal defecate extisted (P < 0.05),the treatment group was better the control group. Two groups improved the abnormal total of WBC without difference (P>0.05). While the curative effect was relation to age, condition, course (P<0.05),such as:the age is smaller,the curative effect is worse,the age is bigger, the curative effect is betterr; the condition is more serious,the curative effect is worse, the condition is lighter,the curative effect is better;the course is shorter, the curative effect is better; the course is longer, the curative effect is worse. The treatment group clinical safety index results indicated the Xie Fei Ping Chuan Mixture was not with toxic side effects to vital organs.Conclusions: The Xie Fei Ping Chuan Mixture is safe and effective in treating the disease of phlegm-heat obstracting lungs of children Bronchio1itis .It is practical.更多还原