【作者】 杨宏志；

【导师】 张传珉；

【作者基本信息】 广西医科大学 ， 肿瘤学， 2009， 硕士

【摘要】 目的:结合文献探讨青年人(≤35岁)大肠癌的临床特征,为青年人大肠癌的早期诊治提供理论依据。方法:回顾性分析1995年至2005年我院收治的71例青年人大肠癌手术病人的临床特点、诊治情况及随访资料,随访其三年生存率,分析它们之间的关系。结果:(1)本组71例病人均为手术病人,其中行根治性手术切除47例(66.2%),行姑息性手术24例(33.8%)。(2)癌肿好发部位为直肠和乙状结肠,显示出向低位大肠高度集中的趋势。(3)临床表现以便血或粘液血便、大便习惯改变、腹部疼痛不适多见。(4)病理类型以管状腺癌、粘液腺癌多见,共55例,占77.5%。(5) Dukes分期以C、D期多见,共46例,占64.8%。(6)术后随访54例,总的3年生存率为59.3%。结论:青年人大肠癌临床症状不典型,分化程度低,恶性程度高,进展快,易误诊、漏诊,手术根治率和生存率低,预后差。如何早发现、早诊断和早治疗(如提高对青年人大肠癌的认识,预防致癌因素,高发地区及人员定期做好普查工作等)是提高手术根治率从而提高生存率的关键。更多还原

【Abstract】 0bjective: To explore clinical character of colorectal carcinoma in young patients(≤35years).Methods: Data of 71 cases treated in our hospital from 1995 to 2005 was analysed retrospectively.Results: All the 71 cases were treated by operation.Radical resection were performed 47 cases(66.2%) , palliative resection to 24 cases(33.8%).Rectum and sigmoid colon are the common sites of colorectal carcinoma in young patients.Main clinical symptoms are changes in hematochezia or blood mucus-stool、bowel movement habit and bellyache.The proportion of adenocarcinoma and mucinous carcinoma was 77.5% . The Dukes stages C and D in this group was 46 cases(64.8% ).54 cases were followed up, the 3-year overall survial rate is 60%.Conclusion:Colorectal carcinoma in young patients has the following features:atypical clinical symptoms,higher malignant degree,being misdiagnosed and missed diagnosed easily,lower rates of radical operation and surviva1.Early detection,diagnosis and treatment are the key of increasing rates of radical operation and surviva1.更多还原