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高血压伴焦虑抑郁症与肾素水平及皮质醇浓度的关系研究
To Study the Relationship between Hypertension Companion Depression or Anxiety and Renin Level and Cortisol Concentration
【作者】 迪丽白尔·塔力甫江;
【导师】 徐新娟;
【作者基本信息】 新疆医科大学 , 内科学, 2009, 硕士
【摘要】 目的:探讨高血压伴焦虑抑郁症与肾素-血管紧张素-醛固酮系统及皮质醇浓度之间的关系。方法:对本院高血压科随机选择的65名高血压患者进行问卷调查,问卷调查的内容包括焦虑自评量表(SAS)和抑郁自评量表(SDS),同时给予这些患者抽血行卧立位肾素-血管紧张素-醛固酮及皮质醇节律检查。对相关数据采用X2检验、秩和检验及相关性分析。结果:高血压合并焦虑症患者与高血压不合并焦虑患者之间性别、凌晨1∶00皮质醇浓度及立位肾素存在差异,有统计学意义(P<0.05),高血压合并抑郁症患者与高血压不合并抑郁症患者之间凌晨1∶00皮质醇浓度有差异,有统计学意义(P<0.05),相关性分析时,高血压合并焦虑症患者与性别、凌晨1∶00皮质醇浓度存在相关性,高血压合并抑郁症与凌晨1∶00皮质醇浓度浓度存在相关性,有统计学意义(P<0.05)。结论:高血压合并焦虑抑郁症与性别、肾素水平、皮质醇浓度有关,皮质醇浓度越高,高血压合并焦虑抑郁症可能性越大。
【Abstract】 Objective: To investigate the relationship between hypertension companion depression or anxiety and renin level and cortisol rhythm. Methods: From our hypertensive department randomly selected 65 hypertensive patients conducted a questionnaire survey, questionnaire included self-rating anxiety scale (SAS) and self-rating depression scale (SDS), at the same time give these patients orthostatic lying blood renin -- angiotensin - aldosterone and cortisol rhythm checks. relevant data using X2 test, rank sum test and correlation analysis. Results: Gender, 1:00 am cortisol concentration and Orthostatic renin have statistical signifiance between hypertension companion anxiety and do not companion anxiety, 1:00 am cortisol concentration have statistical signifiance between hypertension companion depression and do not companion depression. By uesing correlation analysis, hypertension companion anxiety is related with gender,and 1:00 am cortisol concentration; hypertension companion depression is related with 1:00 am cortisol concentration. Conclusion: hypertension companion depression or anxiety is related with gender renin level,cortisol concentration,the higher level of renin and cortisol concentration the greater the likelihood of hypretension companion anxiety and depression.
【Key words】 hypertension; anxiety; depression; renin -- angiotensin– aldosterone; cortisol concentration;