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eIF-4E，VEGF和CD105在胃癌组织中的表达及其临床意义
Expression of eIF-4E, VEGF and CD105 in Gastric Cancer and Its Correlation with Prognosis
【作者】 葛荣峰；
【导师】 华东；
【作者基本信息】 苏州大学 ， 肿瘤学， 2009， 硕士
【摘要】 目的:明确胃癌组织中eIF-4E,VEGF和CD105的表达情况及其临床意义。方法:以53例接受了至少4个疗程的紫杉类、氟尿嘧啶类药物为主的联合化疗的胃癌病人为对象,采用免疫组织化学EnVision法,检测这53例胃癌组织中eIF-4E,VEGF和CD105的表达,同时检测10例癌旁正常组织中eIF-4E,VEGF和CD105的表达作对照。结果:53例胃癌组织中eIF-4E,VEGF和CD105表达率分别是79.3%(42/53)、60.3%(32/53)和100%(53/53)。而在10例正常胃粘膜和癌旁组织中均无表达表达。eIF-4E,VEGF表达与年龄、性别、分化程度无关(P>0.05),与临床分期、淋巴结转移有关(P<0.05)。eIF-4E阳性组、阴性组的中位无病生存期(Disease free survive DFS)分别为8.7月、14.4月,中位总生存期(overall survive OS)分别为14.7月、20.4月,两组的差异均有统计学意义(P<0.05)。VEGF阳性组、阴性组中位DFS分别为8.3月、14.5月,中位OS值分别为17.0月、21.3月,两组的差异均有统计学意义(P<0.05)。通过Spearman秩相关检验发现eIF-4E的表达与VEGF的表达呈正相关(P<0.05),VEGF的表达与CD105的表达呈正相关(P<0.05)。结论:eIF-4E,VEGF和CD105可能不仅与胃癌的发生有关,而且还可能与胃癌的侵袭潜能有关;eIF-4E,VEGF表达可能是胃癌患者预后的判断指标之一。
【Abstract】 Objective: To study the expression of eIF-4E, VEGF and CD105 in gastric cancer tissues and investigate their relationships between their expressions and clinical pathological features.Methods: The expressions of eIF-4E, VEGF and CD105 were detected in 53 tumor samples and from 53 gastric cancer patients treated with 5-fluorourcil and taxans-based adjuvant chemotherapy by immunohistochemical method and 10 normal stomach tissues were used as controls.Results: The expressions of eIF-4E,VEGF and CD105 were 79.3%(42/53),60.3%(32/53)and 100%(53/53)in 53 gastric carcinoma. The eIF-4E and VEGF expression were closely related to the lymph node metastasis and TNM stage (P <0.05), but not to histological differentiation gender and ages.eIF-4E and VEGF were not expression in the normal tissues and paracarcinoma tissues. The disease free survival and the overall survival in the eIF-4E expression positive and negative gastric patients were 8.7mos, 14.7mos and 14.4mos, 20.4mos, respectively (P<0.05). The disease free survival and the overall survival were 8.3mos,17.0mos and 14.5mos,21.3mos in the VEGF expression positive and negative gastric patients, respectively(P <0.05).An positive correlation was found between eIF-4E and VEGF expression (P <0.05).Conclusions: eIF-4E, VEGF and CD105 have different expression in gastric cancer tissues, while no expression in normal tissues and paracancer tissues. The expression of eIF-4E, VEGF and CD105 may not only has related with the development of gastric cancer, but also with the prognosis of gastric cancer.