【作者】 李仔儒；

【导师】 张晓杰；

【作者基本信息】 山东中医药大学 ， 中医外科学， 2008， 硕士

【摘要】 目的:观察荆防蒺藜汤的临床疗效,探讨荆防蒺藜汤治疗慢性荨麻疹可能的作用机理。方法:研究共分两部分。临床研究:将慢性荨麻疹患者60例,随机分为治疗组、对照组各30例。治疗组内服荆防蒺藜汤,对照组内服氯雷他定颗粒,每周复诊1次,4周为1个疗程,1个疗程后观察结果。实验研究:观察荆防蒺藜汤对4-AP致小鼠瘙痒及蛋清致大鼠足跖肿胀的影响。结果:治疗组总有效率83.33%,对照组总有效率86.67%,两组比较差异无显著性(P>0.05)。实验结果显示,荆防蒺藜汤有减少小鼠瘙痒次数,抑制大鼠足跖肿胀的作用。结论:荆防蒺藜汤具有良好的抗过敏,止痒,抑制组胺释放,抗炎的作用,治疗慢性荨麻疹疗效确切,复发率低,不良反应轻微,值得临床推广应用。更多还原

【Abstract】 Objective: To investigate the Jing-Tang Tribulus terrestris the clinical efficacy of anti-Jing Tang Tribulus terrestris the treatment of chronic urticaria possible mechanism. Methods: The study is divided into two parts. Clinical research: 60 patients with chronic urticaria were randomly divided into treatment group and the control group of 30 cases. Oral treatment group Jing-Tang Tribulus terrestris, the control group for Loratadine Oral particles, a referral of the week, four weeks is a course of treatment, a course of treatment after observation. Experimental Study: To observe the anti-Jing Tang on Tribulus terrestris 4 - AP itching and egg white in mice induced by the impact of the foot swelling. Results: In the treatment group, the total efficiency of 83.33%, the control group, the total efficiency 86.67%, the two groups had no significant difference (P> 0.05). Experimental results show that Jing-Tang Tribulus terrestris have anti-inflammatory, inhibiting the mast cells to release histamine role. Conclusion: Jing-Tang Tribulus terrestris has a good anti-allergic, anti-itching, inhibiting the release of histamine, anti-inflammatory role in the treatment of chronic urticaria is effective, low recurrence rate, a slight adverse reactions, it is worth clinical application.更多还原