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中期因子、VEGF-A在卵巢上皮性肿瘤组织中的表达及其临床意义
Expression of Midkine, VEGF-A in Epithelial Ovariantumor Tissues and Clinical Significance
【作者】 曹味纯;
【导师】 李新国;
【作者基本信息】 中南大学 , 妇科肿瘤, 2008, 硕士
【摘要】 目的:研究MK、VEGF—A在卵巢上皮性肿瘤组织中的表达,并探讨其临床意义。结果:MK在卵巢上皮性癌组织中为高表达,与卵巢上皮性良性肿瘤及卵巢交界性肿瘤之间有显著性差异(P<0.01),且与肿瘤临床分期及淋巴结转移相关(P<0.05),但与病理类型、及年龄均无相关性(P>0.05)。VEGF—A高表达于卵巢上皮性癌组织中,与卵巢上皮性良性肿瘤及交界性肿瘤之间有显著性差异,并与肿瘤临床分期及淋巴结转移相关(P<0.05),与病理类型及年龄无相关性(P>0.05)。MK与VEGF-A在卵巢上皮性癌中表达具有一致性。结论:1.MK、VEGF—A的表达上调可能对卵巢上皮性肿瘤的发生发展中起重要作用。2.MK、VEGF—A与卵巢上皮性癌侵袭转移密切相关,其异常高表达可能成为卵巢上皮性癌的预后判断指标。3.在卵巢上皮性癌中,MK、VEGF—A两者之间的表达具有一致性,提示两者可能通过共同的途径参与卵巢上皮性癌的发生、发展及转移过程。
【Abstract】 Objective: To investigate the expression and clinical significances of midkine(MK)、vascular endothelial growth factor—A(VEGF—A) in epithelial ovarian tumors.Results: MK in epithelial ovarian cancer is higher in the expression, and benign tumors and ovarian tumor at the junction between a siginificant difference (P <0.01), and the clinical stage and tumor metastasis and related (P <0.05), But with the pathological type and age were not related (P> 0.05). VEGF-A high expression in epithelial ovarian cancer, and benign tumors and ovarian tumor at the junction between a significant difference, and clinical stages of tumor metastasis and related (P <0.05), and no pathological type and age Correlation (P> 0.05). MK and VEGF-A in epithelial ovarian cancer in the expression of consistency.Conclusion: (1)、MK, VEGF-A may increase the expression of epithelial ovarian tumors and development play an important role.(2)、MK, VEGF-A with epithelial ovarian cancer is closely related to the invasion and metastasis, the expression may become abnormal epithelial ovarian cancer prognostic indicators.(3)、Epithelial ovarian cancer, MK, VEGF-A between the expression of consistency, suggesting that the two may be the way through the common epithelial ovarian cancer to participate in the occurrence and development and transfer process.
【Key words】 MK; VEGF-A; epithelial ovarian tumor; immunohistochemistry;
- 【网络出版投稿人】 中南大学 【网络出版年期】2009年 01期
- 【分类号】R737.31
- 【下载频次】50