【作者】 刘丹；

【导师】 罗月中；

【作者基本信息】 广州中医药大学 ， 中医内科学， 2008， 硕士

【摘要】 【目的】:观察中西医结合治疗轻度活动期狼疮性肾炎(LN)的临床疗效及对复发率、不良反应发生率的影响。【方法】:将40例轻度活动期的狼疮性肾炎患者按1∶1比例随机分为治疗组和对照组。治疗组在激素治疗的基础上,配合中药辨证加减治疗,对照组单使用激素治疗,观察各组病例中患者纳入时及治疗1年期间临床症状、体征、血常规、补体C3、C4、24h尿蛋白定量、肝肾功能等指标,以观察患者的临床疗效及复发、不良反应发生情况。【结果】:(1)治疗组总有效率(95.0%)与对照组总有效率(70.0%)相比有显著差异(P＜0.05):(2)治疗组与对照组复发率相比较,差别有统计学意义(P＜0.05);(3)治疗组与对照组不良反应发生率相比较,差别有统计学意义(P＜0.05);(4)治疗组治疗后24h尿蛋白定量下降显著低于对照组(P＜0.01);(5)治疗组治疗后补体C3、C4值显著高于对照组(P＜0.01):(6)治疗组可有效减少激素使用量,与对照组比较有非常显著差别(P＜0.01)。【结论】:在提高轻度活动期狼疮肾患者的临床疗效、控制LN复发、降低不良反应的发生率、减少激素使用量、降低尿蛋白等方面,中西医结合治疗组疗效优于激素组。更多还原

【Abstract】 [Purpose] : To observe the clinical effect of the treatment combining traditional Chinese and western medicine on lupus nephritis (LN) in Mildly active and analyze the rate of relapsing , the incidence of adverse reactions.[Method] : 40 cases of patients with lupus nephritis in Mildly active, randomly divided into treatment and control groups by 1:1 ratio. Treat the conventional treatment group with Chinese medicine Syndrome addition and subtraction on the basis of hormone therapy, and with conventional western medicine treatment for the control group. Observe the treatment of symptoms and signs, blood, complement C3, C4, 24h urine protein, liver and kidney function indicators of patients and analyze the patients’ clinical efficacy and recurrence, the occurrence of adverse reactions in each group during one year.[Results] : (1) There is significant difference between the total efficiency of treatment group (95.0%) and the control group (70.0%) (P <0. 05) ; (2) it has statistical significance of the difference between the relapsing rate of the treatment group and the control group (P <0. 05); (3) it has statistical significance of the difference between the adverse reaction rates of the treatment group and the control group (P <0.05); (4) the treatment group’ 24hs urine protein is significant lower than the control group’ after treatment (P <0. 01) ; (5) the treatment group’ complement C3、C4 is significant richer than the control group’ after treatment (P<0.01) . (6) compared with the control group the treatment group can be effective in reducing the use of hormones, and the difference between them is very significant(P<0. 01).[Conclusion] : The treatment group’ s effect is better than the control group’ s on improving the clinical symptoms, controlling LN recurrence, reducing the incidence of adverse reactions to reduce the use of hormones, lowering urinary protein.更多还原