【作者】 应讷江；

【导师】 屈一新；

【作者基本信息】 北京化工大学 ， 化学工程， 2007， 硕士

【摘要】 头孢呋辛酯是一种广谱抗菌药。它有三种晶型：α、β和无定型。但是只有β和无定型具有生物可利用特性。而市场上注册生产的只有无定型的头孢呋辛酯。本文介绍了利用超临界抗溶剂结晶法实现头孢呋辛酯的微粉化和无定型化。本文介绍了依靠一套连续的气体抗溶剂实验装置——超临界抗溶剂结晶仪，以头孢呋辛酯—丙酮一CO₂物系为研究对象，利用超临界流体抗溶剂过程制备了无定型头孢呋辛酯颗粒，从而验证了装置的可靠性。实验通过扫描电子显微镜、X-射线衍射法和红外吸收光谱法确定了利用超临界抗溶剂结晶法制备的头孢呋辛酯晶型为无定型；同时，对不同的实验条件（温度，结晶压力，操作气液比，头孢呋辛酯溶液浓度和喷嘴）对结晶颗粒粒径的影响进行了研究。结果表明，在以上实验因素中，结晶压力、温度、头孢呋辛酯溶液浓度和CO₂与丙酮溶液气液比这四个因素对实验结果影响最大。实验改变结晶压力、头孢呋辛酯溶液浓度和CO₂与丙酮溶液气液比这三个因素的单独实验，分析了这三个因素对实验结果的单独影响（结晶压力升高，头孢呋辛酯晶体平均粒径减小；头孢呋辛酯浓度升高，头孢呋辛酯晶体平均粒径增大；CO₂与丙酮溶液气液比增大，头孢呋辛酯晶体平均粒径减小），并分析了可能存在的原因，实验成功制备了粒径较小的无定型头孢呋辛酯颗粒。更多还原

【Abstract】 Cefuroxime axetil belongs to cephalosporim antibiotic. Here are three polym-orphs which areα,βand the unformed for cefuroxime axetil but onlyβand the unformed are able for us, however, the unformed cefuroxime axetil is permitted to produce exclusively. The paper introduces the way to get Cefuroxime axetil power and the unformed cefuroxime axetil by means of supercritical antisovent crystallization.The paper introduces that we use a continuous gas supercritical antisovent instrument to get cefuroxime axetil power by supercritical antisovent process. Our research object is the object system of cefuroxime axetil- acetone- carbon dioxide. The paper uses three ways of SEM, X-ray diffraction and Infrared spectrum to check the unformed cefuroxime axetil by GAS ; and we also check the reliability of the instrument. At the same time, we do much research about the influence of the crystal size in different testing conditions (temperature, crystallization pressure, the value of gas and fluid flow rate, cefuroxime axetil concentration and nozzles).The result is that temperature, crystallization pressure, cefuroxime axetil concentration and the value of gas and fluid flow rate are the most important in all these test conditions. We also check the separate impact of these three test conditions (crystallization pressure rises, the crystal average size reduces; concentrations rise, the crystal average size increases; the value of gas and fluid flow rate rises, the crystal average size reduces).We also analysis the possible reasons. The unformed cefuroxime axetil which has smaller crystal average size is produced successfully.更多还原