【作者】 蒋娟雯；

【导师】 黄剑奇；

【作者基本信息】 浙江大学 ， 口腔临床医学， 2007， 硕士

【摘要】 研究目的：通过回顾分析口腔颌面部恶性淋巴瘤的临床特点、诊断、治疗和预后，提高口腔颌面外科医生对恶性淋巴瘤的认识，达到早期临床诊断。方法：对37例口腔颌面部恶性淋巴瘤患者的临床资料进行回顾性研究。结果：37例口腔颌面部恶性淋巴瘤中，男∶女=1.31∶1，中位年龄55岁。发病部位依次为颌下、颏下7例、上颌部7例，腭部6例，腮腺5例，舌根部5例，颈上部4例，颊部2例，牙龈1例。37例全部是NHL，B细胞淋巴瘤27例(72.97％)，T／NK细胞淋巴瘤9例(24.32％)，1例未确定细胞来源。首次就诊均误诊为炎症和相应部位的良、恶性肿瘤。主要采用综合治疗。结论：口腔颌面部恶性淋巴瘤首诊中易被误诊和漏诊；组织活检以明确诊断；综合治疗是本病的主要治疗手段。更多还原

【Abstract】 Objective: By studying retrospectively the clinical characteristics, diagnosis , treatment and prognosis of malignant lymphoma in oral and maxillofacial region, to enhance surgeon’s recognition of the disease, lead to early clinical diagonosis. Methods: Clinical data of 37 cases were obtained from patient files. Each patient’s complete record were reviewed. Results: Of a total of 37 cases malignant lymphoma recorded in a 5-year period, the ratio of male/female was 1:31 (21/16), and median age of the patients was 55 (range, 8-82 years old). Affected anatomic sites included: submaxillary and submentum (7), maxilla(7), palate(6), salivary gland(5),root of tongue(5), neck(4), cheek(2), gingival(1). All of the cases are NHL, B cell lymphoma 27 (72.97%) , T/NK cell lymphoma9 (24.32%), one case’s cell origin was uncerten. All of them was misdiagnosed for inflammation and corresponding sites benign or malignant tumor at first visit. Combined therapy was chief treatment method. Conclusion: ① Oral and maxillofacial malignant lymphoma was often misdiagnosed for other common oral diseases. ②Early diagnosis depended on a thorough examination and biopsies from suspected lesions. ③Chemotherapy combined with radiotherapv and operation is proved to be the most efficient therapeutic means. ④If discovered and treated early, malignant lymphoma in oral and maxillofacial regions has an better prognosis.更多还原