节点文献

水分子扩散加权成像在肝脏占位性病变鉴别诊断中的研究

Differential Diagnosis Study of Diffusion Weighted MR Imaging in Focal Hepatic Lesions

【作者】 谭军

【导师】 袁曙光; 闫东;

【作者基本信息】 昆明医学院 , 影像医学与核医学, 2006, 硕士

【摘要】 【目的】探讨水分子扩散加权成像(diffusion weighted imaging,DWI)在肝脏占位性病变中的诊断、鉴别诊断价值。 【材料与方法】对7例正常志愿者,29例病人的腹部正常脏器;98例肝脏局灶性病变共172个病灶,其中肝囊肿32例57个病灶,肝血管瘤27例39个病灶,肝细胞癌24例32个病灶,转移性肿瘤15例44个病灶进行扩散加权成像,并计测表观扩散系数(apparent diffusion coefficient,ADC)。DWI序列所选用b值分别为0,50,500。同时对所有受检者行常规T1WI、T2WI,其中75例肝脏占位性病变行MR动态增强成像,观察病灶不同时相强化模式。 【结果】b值取(0,50)获取肝脏占位性病变的平均ADC值(除外肝囊肿)均明显大于用b值取(0,500)得到的平均ADC值(P<0.05)。b=50s/mm2时计测的肝囊肿、肝血管瘤、肝细胞癌、转移瘤的平均ADC值分别为:(3.71±0.30)×10-3mm2/s、(7.74±0.74)×10-3mm2/s、(5.16±0.57)×10-3mm2/s、(4.94±0.45)×10-3mm2/s。b=500s/mm2时计测的肝囊肿、肝血管瘤、肝细胞癌、转移瘤的平均ADC值分别为:(3.35±0.31)×10-3mm2/s、(1.72±0.20)×10-3mm2/s、(1.09±0.21)×10-3mm2/s、(1.18±0.14)×10-3mm2/S。无论取低、高b值,肝囊肿、肝血管瘤与肝细胞癌及转移瘤之间平均ADC值差异显著(P<0.001)。但肝细胞癌与转移瘤之间ADC值多有重叠,鉴别诊断有一定困难。在常规MR扫描中,肝脏占位性病变在T1WI以低信号为主,在T2WI大部为高或稍高信号强度。在动态增强成像中,28.1%肝细胞癌、25.6%肝血管瘤与31.8%肝转移瘤可见到门脉期及延迟期强化。

【Abstract】 [Objective] To evaluate the value of diffusion weighted magnetic resonance imaging in diagnosis and differential diagnosis of focal liver lesions.[Method] Diffusion weighted MR imaging and measurement of apparent diffusion coeffient (ADC value) were performed in 36 normal cases , 98 patients with172 local hepatic lesions( including hepatic cyst 57, hemangioma 39, hepatic carcinoma 32, metastasis 44) .And ADC values were calculated.. The b values were 0, 50, 500. T1WI、 T2WI was performed in all livers. And multiphase dynamic enchancement was performed in 75 patients to observe dynamic contrast-enchanced change of the lesions.[Result] The average ADC values of focal hepatic lesions with lower b value(0,50) were significantly higher than that with higher b value(0,500). except hepatic cyst . when b=50 s/mm2, average ADC values of hepatic cyst、 hemangioma、 hepatic carcinoma and metastasis were (3.71±0.30)×10-3mm2/s、 (7.74±0.74) ×10-3mm2/s、 (5.16±0.57) ×10-3mm2/s、 (4.94±0.45) ×10-3mm2/s. when b=500 s/mm2, average ADC values of hepatic cyst、 hemangioma、 hepatic carcinoma and metastasis were(3.35±0.31) ×10-3mm2/s、 (1.72±0.20) ×10-3mm2/s、 (1.09±0.21) ×10-3mm2/s、 (1.18±0.14) ×10-3mm2/s. whether lower or higher b value, the average ADC value of malignant masses(hepatic carcinomas、 metastasis) was significantly different from that of hepatic cysts and hemangiomas(P<0.001). yet, the ADC values of metastatic tumor overlapped with those of hepatic carcinoma. In routine MRI, most of liver masses showed low signal in T1WI and high or little high signal in T2WI. In dynamic contrast

  • 【网络出版投稿人】 昆明医学院
  • 【网络出版年期】2007年 01期
  • 【分类号】R445.2
  • 【下载频次】43
节点文献中: