【作者】 张川林；

【导师】 严桂珍；

【作者基本信息】 福建中医学院 ， 中医内科学， 2005， 硕士

【摘要】 目的:本篇文章通过观察30例严氏祛风除痒止咳方对外感风热、肺肾两虚型咽源性咳嗽患者的临床症状、体征、中医证候的影响、不良反应等,并以西药为对照组(利巴韦林、西替利嗪、复方甘草合剂),旨在客观评价严氏祛风除痒止咳方治疗咽源性咳嗽的临床疗效和安全性,为其方在临床上的推广使用提供依据,为新药的开发和利用奠定坚实的基础。 资料与方法:参照1993年《中药新药治疗慢性咽炎的临床研究指导原则》的西医诊断标准,参照1993年《中药新药治疗慢性咽炎的临床研究指导原则》及《中医诊断学》拟定本病外感风热、肺肾两虚证的症状。严格按照以上标准选择咽源性咳嗽病人60例(外感风热、肺肾两虚证),随机分为试验组和对照组各30例。试验组服用严氏祛风除痒止咳方,对照组服用(利巴韦林、西替利嗪、复方甘草合剂),疗程均为一周。分别观察患者症状、体征在治疗前后的变化,并于治疗前后行血常规、肝功能、肾功能等实验室检查,记录其不良反应,从而评判其疗效、耐受性及安全性。 结果:试验组和对照组治疗外感风热、肺肾两虚型咽源性咳嗽均有效;但两组疗效组间差异明显。两组对中医证候疗效总有效率分别为90%、66.7%,试验组和对照组比较差异显著(p<0.05)。治疗后积分均较治疗前改善明显(p<0.01),且组间差异明显(p<0.05)。两组治疗前后血常规、肝肾功能均无明显变化,试验组服药后无明显不良反应发生。 结论:严氏祛风除痒止咳方对外感风热、肺肾两虚型咽源性咳嗽患者疗效显著,在改善症状体征同时,无明显不良反应,是一种治疗咽源性咳嗽的安全有效中药制剂。更多还原

【Abstract】 Objective:To observe efficacy and adverse effects of Recipe for Yan-Removing Wind and Dispersing the Itch and Stopping Cough in treating Pharyngal Cough of the type of exogenous wind-heat and deficiency of lung-kidney on clinical symptoms, sign, TCM syndrome ,and taking chemical medicines as the control, to objectively evaluate the efficacy and safety of Recipe for Yan-Removing Wind and Dispersing the Itch and Stopping Cough in treating Pharyngal Cough.Methods:To select sixty patients from the combination of <The Principle in Clinic Study of TCP> in 1993 and <Diagnostics of TCM> Sixty patients with Pharyngal Cough of exogenous wind-heat and deficiency of lung-kindey entered the study and were randomized to treatment and control groups,30 case in each.The treatment group was given Recipe for Yan-Removing Wind and Dispersing the Itch and Stopping Cough, The control was given chemical medicine; the treatment duration was one week. The conditions of blood, liver , renal function were determined at the beginning and the end of the trail respectively.We observed the changes of clinical symptoms, sign, TCM syndrome, the adverse effects were illustrated in words.Results:In treatment group, score for clinical syndromes were reduced from 31.70 ±4.90 to 15.10 ± 6.74 after one week treatment, clinical syndromes were improved,the difference between the treatment group and the control group was significant, there was no significant difference of adverse reaction between the two groups.No significant difference changes ofliver function, renal function,blood routine test were found in both groups. Conclusions:Recipe for Yan-Removing Wind and Dispersing the Itch and Stopping Cough has significant treating effects in Pharyngal Cough of the type of exogenous wind-heat and deficiency of lung-kidney. Recipe for Yan-Removing Wind and Dispersing the Itch and Stopping Cough is a safe and effective drug of Chinese herbal medicine for Pharyngal Cough.更多还原