【作者】 宋新安；

【导师】 黄海；

【作者基本信息】 福建中医学院 ， 中医临床基础， 2004， 硕士

【摘要】 目的：《伤寒论》解郁清气法(小柴胡汤合栀子豉汤)治疗焦虑症的临床研究。 方法：本研究采用随机分组的原则将80例病例分为中药研究组(小柴胡汤合栀子豉汤的科学中药)与对照组口服阿普唑仑(alprazolam)，0.5mg，tid，治疗6周观察其结果。 结果：(1) 焦虑症患者经两组治疗前后Hamilton焦虑量表(HAMA)(x±s)比较，治疗后与治疗前比较，经t检验有显著差异*P＜0.05，**P＜0.01。两组总治疗后减分经x~2检验P＞0.05，两组无显著性差异。(2) 经两组治疗前后HAMA因子平分比较(x±S)，治疗后与治疗前比较，经t检验有显著差异*P＜0.05，**P＜0.01。两组总治疗后减分经x~2检验P＜0.05，有显著性差异。(3) 经两组治疗前后Zong焦虑自评量表(SAS)减分比较注治疗后与治疗前比较，经t检验有显著差异*P＜0.05，**P＜0.01。两组总治疗后减分经x~2检验P＞0.05，无显著性差异。(4) 经两组治疗前后临床疗效总量表(GGI)比较，治疗后与治疗前比较，两组总治疗后减分经x~2检验P＞0.05，无显著性差异。(5)两组治疗后，其副作用的发生如困倦、口干、口苦、便秘、头晕、头痛、恶心、无力、视力模糊，小柴胡汤合栀子豉汤明显少于alprazolam(P＜0.01)，有显著性差异。 结论：临床研究表明，该药毒副作用甚小，疗效相当，特别对伴有明显躯体性焦虑症状者疗效更佳。更多还原

【Abstract】 Objective: To observe the clinical effect of the treating method of reliving depression and clearingheat, which comes from Treatise on Exogenous Febrile Disease, on anxiety. Minor Decoction of Bupleurum in combination with Decoction of Gardeniae and Sojae Praeparatura was applied in the study.Methods: 80 cases of anxiety were divided randomly into treatment group treated with Chinese herbs, which were made into scientific form, and control group treated with Alprazolam, 0.5mg each time, thrice daily. The therapeutic course lasted for 6 weeks.Results: (1) According to HAMA, significant difference was observed in both groups before and after treatment (*P<0. 05, **P<0. 01 respectively, byt-test). As to the decreased value, There was no significant difference between 2 groups(P>0. 05, by x test). (2) According to HAMA factor grade, significant difference was observed in both groups before and after treatment (*P<0.05, **P<0.01 respectively). As to the decreased grade after treatment, There was no significant difference between 2 groups (P>0. 05, by X* test). (3) According to SAS, significant difference was observed in both groups before and after treatment (*P<0. 05, **P<0. 01 respectively, by t-test). As to the decreased value after treatment, There fas no significant difference between 2 groups(P>0. 05, by x test). (4) As to the decreased value of GGI after treatment, There was no significant difference between 2 groups(P>0.05, by X test). (5) After treatment, there were less side effects in the treatment group than in the control group (P<0. 01) such side effects includes fatigue, dry mouth, bitter mouth, dry. stool, dizziness, headache, nausea, tiredness, blurred vision.Conclusion: The effect of Chinese herbs of relieving anxiety and clearing heat is equal to that of alprazolam. This treating method is better for corporality anxiety.更多还原