磁性药物载体交联淀粉空白球制备和生物降解性能研究

【作者】 商菊清；

【导师】 黄可龙；

【作者基本信息】 中南大学 ， 应用化学， 2004， 硕士

【摘要】 本文研究了作为药物载体的磁性交联淀粉纳米球的制备方法和性能。主要从以下几个方面展开研究： 研究了交联淀粉球的制备方法。在正交设计的基础上，采用反相微乳液法，控制不同的反应条件，制备出了粒径从微米级到纳米级可控的交联淀粉球，并通过多元线性回归的方法导出了预测淀粉球粒径的多项式回归方程。 采用傅立叶红外光谱分析、核磁共振氢谱和扫描电子显微镜对交联淀粉球的结构和性能做了详尽的研究。研究发现，交联度对交联淀粉的性质有着极大的影响。FTIR方面，共有3400cm^-1、1640cm^-1，1600 cm^-1、1250cm^-1～1269cm^-1的光谱带和1047cm^-1与1022cm^-1之间的比值对交联度的变化极为敏感，随着交联度的改变而有着不同的改变趋势。同时，交联度的变化也引起淀粉溶解性能和吸水性能的改变。高交联淀粉溶解性能降低，而吸水性能增强。交联反应的实质就是不断以交联键取代淀粉分子内的氢键。 为了考察交联淀粉的降解性，采用葡萄糖淀粉酶水解它。研究表明，在交联度分别为0、2、6、12、20的情况下，交联度为6的交联淀粉着有最好的降解性能。 应用原位法合成了平均粒径为60nm，比重1.37g／cm³，比表面积为73.0m²／g的磁性交联淀粉纳米球。球内铁氧体和交联淀粉之间以化学键连接，这种连接方式对磁性球的降解性能产生了影响。同时对磁性交联淀粉球的成核过程做了热力学上的推导。更多还原

【Abstract】 As a drug carrier, study on nanometer magnetic crosslink starch sphere was reported in this paper as follows:Firstly, a research of preparation of crosslink starch sphere had been conducted. Based on orthogonal design, crosslink starch sphere was synthesized whose mean diameter varied from micron to nanometer in inverse microemulsion through controlling reaction conditions. Also, we found a polynomial regression equation which could prognosticate the diameter of crosslink starch by multiple linear regression.Secondly, it was studied in particular on structure and property of crosslink starch with FTIR, SEM and HNMR analysis. It was found that property of crosslink starch was very sensitive to its crosslink degree. In FTIR, around 3400cm-1?1640cm-1?1600 cm-1?from 1250cm-1 to 1269cm-1 and the ratio between 1047cm-1 and 1022 cm-1 were varied with crosslink degree changed. Meanwhile, dissolving and bibulous performance were also changed with crosslink degree. High crosslink starch nearly didn’t dissolve in boiled water and could sop up more water. It was believed that substantially crosslink reaction substituted hydrogen bond for crosslink bond continually.In order to observe the degradation performance of crosslink starch sphere, we designed a reaction with glucose amylase. The result of study indicated that crosslink starch with crosslink degree 6 had the best degradation performance in comparison with 0, 2, 12, 20.Finally, magnetic crosslink starch was synthesized in situ. The particle size of it was around 60nm, density 1.37g/cm , specific surface area 73.0m2/g. Crosslink starch and ferrite were linked with chemical bond. The exist of such chemical bond had some effect on degradation performance of magnetic crosslink starch, that is, not as good as crosslink starch. The nucleus-form process of magnetic cross-linked starch microsphere was deduced on thermodynamics.更多还原