【作者】 刘维明；

【导师】 隗继武；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2004， 硕士

【摘要】 本文旨在运用中医和中西医结合理论，从理论、临床和实验研究诸方面探讨幽门螺杆菌相关消化性溃疡的病因病机、治疗原则及中药健胃清幽片的疗效机理。研究表明，HP相关消化性溃疡的基本病机是本虚标实，实邪感染为其标，脾胃虚弱为其本。立法健脾益胃扶正、清热解毒祛邪。组方健胃清幽片。临床研究表明：健胃清幽片治疗HP相关溃疡病症状总有效率94． 0%，消化性溃疡有效率87． 1%，均高于对照组78． 3%、69． 9%。HP总抑杀率治疗组83． 0%，对照组81． 7%，两者相似。实验研究表明：健胃清幽片在抑杀HP的同时，可提高免疫功能并改善胃粘膜微环境，增强组织修复能力，通过改善胃超微结构，提高机体免疫力，改变HP赖以生存的条件，从而达到促进溃疡愈合，减少复发的作用，具标本兼治、价格低廉、服用方便的特点。更多还原

【Abstract】 We have inquired into the etiology and pathogenesis of H. pylori associated Peptic uler disease and its treating principle by using the theory of Traditional Chinese Medicine (TCM) and combination of TCM and Western Medicine .By means of clinical and experimental researches, we have explored the mechanism of the curative effect of Jianweiqingyoupian on H. pylori associated peptic uler disease. We found that the fundamental pathogenesis H. pylori associated Peptic uler disease is the deficiency in its principal aspects and the excess in its secondary aspects. The exogenous pathogenic factors is exterior and qi deficiency in the spleen and stomach is its interior. Therapeutic methods: Strengthening anti-pathogenic qi and eliminating pathogenic factors. Prescription: Tablet of Jianweiqingyoupian. The result of clinical research showed that the treatment group had 94.0 percent in effective ate and 87.10 percent in the alleviated rate of Peptic uler disease , superior to contrast group with 78.30 percent and 69.90 percent respectively. Treatment group is similar to contrast group in killing HP rate, the former is 83.00 percent and the latter is 81.70 percent. The experimental research indicated that Jianweiqingyoupian can increase immune functions, improve tissue, therefore decrease relapse of Peptic uler disease.更多还原