【作者】 刘显涛；

【导师】 郑翠娥；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2004， 硕士

【摘要】 本研究的目的是通过临床与实验研究观察肺抑瘤合剂治疗中晚期肺癌的疗效并探讨其作用机理。方法：将78例经细胞学、病理学确诊的原发性支气管肺癌患者随机分为以本药和化疗的联合治疗组(简称治疗组，39例)与单纯化疗组(简称对照组，39例)进行临床疗效观察；实验研究观察本药对p53抑癌基因的调控作用。结果：临床结果表明治疗组在改善症状、提高生活质量、稳定病灶、延长生存期、提高化疗临床疗效及减轻化疗毒副作用等方面均优于对照组(P<0． 05或P<0． 01) 。动物实验表明本药能显著抑制肺癌小鼠局部肿瘤生长及自发性癌转移；能明显延长荷瘤小鼠生存期；其机理可能在于肺抑瘤合剂对p53抑癌基因的调控。更多还原

【Abstract】 Objective: To observe the effects on the treating the lung cancer and the influence of the expression for p53 protein with Fei Yi Liu He Ji. Methods:78 confirmed primary lung cancer patients were randomly divided into two groups . 39 patients of the treated group were treated with Fei Yi Liu He Ji mixture and chemotherapy. 39 patients in control group were treated with chemotherapy, and the clinical therapeutic effects were observed. In the mouse experimental study, we observed the 4 groups’ effects of treating the mouse model of lung cancer with Fei Yi Liu He Ji, Fei Yi Liu He Ji plus p53 protein and the p53 protein. Results: The clinical study showed the therapeutic effects of the treated group were more significant than it of the control group(P<0. 05 or P<0. 01).We also found the immune index increased and the toxic reaction caused by the chemotherapy reduced significantly in the treated group. In the experimental study, Fei Yi Liu He Ji and p53 gene can obviously inhibit the growth of tumor .The difference wes significant between the four groups, among which the combined Fei Yi Liu He Ji and p53 gene enhance the inhibiting effect more markedly. The survival period of tumor bearing nude mice was prolonged after transfecting p53 gene or Fei Yi Liu He Ji alone, p53 gene or Fei Yi Liu He Ji jointly can prolong the survival period significantly. Conclusion: Fei Yi Liu He Ji mixture plus chemotherapy has better effects on inhibiting tumor than chemotherapydoes. And Fei Yi Liu He Ji mixture can reduce the toxic reaction caused by the chemotherapy. The functionary mechanism for its restraining cancer may be relative to its restraining the expression for the protein p53.更多还原