【作者】 许微；

【导师】 王江；

【作者基本信息】 天津大学 ， 控制理论与控制工程， 2004， 硕士

【摘要】 神经传导速度的测定是较为敏感和重要的神经功能评价指标之一，已广泛用于神经性疾病的临床诊断和愈后功能检查，同时在电生理基础研究和运动医学研究中也具有十分重要的意义。到目前为止，神经纤维动作电位传递速度的实验测量技术已发展的较为成熟，其中比较典型的方法是两点测试法，这种测量方法虽然简单，但误差较大，且单纯的实验方法缺乏理论依据。20 世纪中期，大批学者曾对兴奋在有髓及无髓神经纤维上的传递速度与纤维直径及温度的关系做了仿真，仿真结果与实验结果相吻合。但是，到目前为止对于动作电位在无髓鞘及有髓鞘神经纤维上的传递速度的定量分析却很少。本文首先分析了动作电位在无髓神经纤维上的传递机制，得出了可用跨膜电流的移动速度来等效动作电位传递速度的结论，结合电缆模型与 H-H 模型，建立了动作电位传递期间神经纤维的等效电路模型，并在此基础上推导出计算传递速度的公式，对其进行了验证。接下来，应用与无髓鞘神经纤维相类似的方法，分析了动作电位在有髓鞘神经纤维上的传递机制，同样得出了可用跨膜电流的移动速度来等效动作电位传递速度的结论，利用 McNeal 模型和 CRRSS 模型，建立了有髓神经纤维在兴奋传递期间等效电路模型，并推导出了速度的计算模型。最后，分别仿真了有髓及无髓神经纤维细胞膜各参数的变化对兴奋传递速度的影响，增强了两个计算模型的可应用性。更多还原

【Abstract】 The nerve conduction velocity is one of the important and sensitive deliberatedindex of the nerve function, which is applied widely into the clinic diagnosis andfunction examination after healed of some neural disease. And it is also veryimportant for the basic research on nerve electrophysiology and the research onmovement medicine. Up to now, the experimental measure technology of the velocityof action potential propagated along nerve fibers, in which the typical method is thetwo spots measurement. Although this method is very simple, the error is great, andthe experimental method lacks of the theoretic basis. In the middle of 20 century, agreat lot of scholars simulated the relation between the velocity of action potentialpropagated along a myelinated fiber or an unmyelinated fiber and the fiber diameteror the temperature. The results were according to the experimental results. But by far,there are lacking in the quantitative analysis of the velocity of action potentialpropagated along a myelinated fiber and an unmyelinated fiber. In this paper, we first analyze the mechanism of action potential propagated alongan unmyelinated fiber, and present a hypothesis that the velocity of transmembranecurrent is the equivalent of the propagation velocity of action potential. Then usingthe H-H model and the cable equation we obtain the formula of the velocity. Insuccession, we apply a similar method to analyze the mechanism of action potentialpropagated along a myelinated fiber. Using the McNeal model and the CRRSS model,we obtain the formula of the velocity. In the end, we simulate the influence of eachmembrane parameter to the propagation velocity for myelinated fibers andunmyelinated fibers, respectively, which can enhance the usability of the twocomputational models.更多还原