【作者】 李世强；

【导师】 王晓静；

【作者基本信息】 天津大学 ， 化工过程机械， 2004， 硕士

【摘要】 莲心碱是天津达仁堂制药二厂开发的舒心降压胶囊中主要的药效成分。本文就动态膜滤技术在莲心碱的提纯和叶绿素去除中的应用进行了一系列实验研究。文中针对莲心碱和叶绿素的特点，建立了莲心碱和叶绿素浓度检测的简便定量分析方法。探索了对莲子心醇提液进行物化处理以实现莲心碱和叶绿素膜分离的可行性，通过考察溶液的物料浓度、PH 值对叶绿素絮凝分离效果和莲心碱回收率的影响，初步确定了莲子心醇提液预处理的适宜条件。 本文采用平板动态膜滤器，重点考察了操作压力、物料浓度、物料主体流速等操作条件对膜滤过程的影响。通过动态膜滤过程中总阻力、浓差极化层阻力Rbl、沉积层阻力Rc和膜阻力的增加ΔRm的形成、变化及影响因素的分析，研究不同操作条件对膜滤的阻力分布、稳态渗透速率以及分离效果（如莲心碱回收率及叶绿素截流率）的影响，并初步确定出莲心碱膜分离的实验室操作条件。为膜分离的工程放大中有效降低膜污染，提高膜渗透速率和分离效率指明方向。 本文还通过对膜滤过程中各部分膜滤阻力的理论推导，结合实验数据的分析拟合，得出了在本实验条件下的稳态渗透速率、浓差极化层阻力Rbl、沉积层阻力Rc、膜阻力的增加ΔRm的计算模型，对今后的工程应用有一定的指导意义。更多还原

【Abstract】 Licnsinine Lie is the primary pharmacal component of capsule for relaxing heartand stepping down blood pressure, which is developed by the second pharmacyfactory of Tianjin Darentang. In this paper, the crossflow membrane filter is applied toremove chlorophyll from the lotus alcoholic liquor and get Licnsinine Lie finally. Thesimple mensuration for Licnsinine Lie and Chlorophyll concentration is founded onthe characteristics of Licnsinine Lie and Chlorophyll. Feasibility of separatingLicnsinine Lie from Chlorophyll with membrane is researched by experiments on thelotus alcoholic liquor. Appropriate conditions of the lotus alcoholic liquorpretreatment is established by studying the effect of feed concentration and PH valueon recovery rate of Licnsinine Lie and removal rate of chlorophyll. In this paper, the flat crossflow membrane filter is used in experiments to researchthe effect of operation pressure, feed concentration and feed velocity on the process ofmembrane filtration. The form, change and effect factors of the resistances areanalyzed in the crossflow membrane filtration. And the resistances include totalresistance Rt, concentration polarization resistance Rbl, cake resistance Rc andincrement of membrane resistance ΔRm. The conditions of laboratory operation forLicnsinine Lie separation with membrane is established by studying the effect ofdifferent operation conditions on resistance distribution, steady permeate velocity andseparation efficiency. The direction of increasing steady permeate velocity andseparation efficiency is pointed out. The mathematics model about the crossflow membrane filtration is founded ontheoretic deducing and experimental data regression for calculating steady permeatevelocity, total resistance Rt, concentration polarization resistance Rbl, cake resistanceRc and increment of membrane resistance ΔRm.更多还原