【作者】 祁莉萍；

【导师】 汪太平；

【作者基本信息】 安徽医科大学 ， 内科学， 2001， 硕士

【摘要】 背景：丹参作为传统中药，在心血管疾病治疗方面有独特优势，许多动物实验及一些临床研究表明丹参液能作用于冠心病心绞痛发生发展的多个环节，中断该疾病病理过程而有效治疗心绞痛，可以改善心功能，主要是左室舒张功能，其作用机制主要与抗氧化作用有关，但是，在人体研究中，很少将其临床疗效与抗氧化机制做系统的相关分析，丹参液改善心绞痛患者心功能的研究也较少，甚至很少有临床研究将心功能的改善与其抗氧自由基机制做相关分析，本研究将以稳定型心绞痛患者为研究对象对上述问题探讨。内容：本文旨在研究丹参液对稳定型心绞痛患者抗氧化作用和心功能改善作用。方法：将80例该型患者随机分成两组，分别用基础药物治疗和加用丹参液治疗10天，除了监测临床指标外，还测量了氧化和抗氧化指标：丙二醛（MDA），超氧化物歧化酶（SOD），谷光甘肽过氧化物酶（GSH-Px），以及超声心动图测量心脏舒张和收缩功能。结果：两组患者的年龄、性别、基础用药及共存疾病具有可比性，治疗后两组比较，1.MDA、SOD、GSH-Px、SOD/MDA、△MDA、△SOD、△GSH-Px有显著差异，丹参液组改善明显，P＜0.05或者P＜O.01。2.临床症状及心电图改善与氧化、抗氧化指标显著相关，P＜0.05。3.丹参液组舒张功能IRP、Ei有显著改善，P＜O.05，对收缩功能无改善。4.心绞痛症状改善与舒张功能改善显著相关，P＜0.05或者P＜0.01。5.舒张功能改善与氧化、抗氧化指标改善显著相关，分别P＜0.01、 安徽医科大学硕士研究生论文 P＜0．05。 结论：丹参液治疗稳定型心绞痛，临床症状改善与其抗氧化机制有关， 本资料显示可以改善患者的舒张功能，而心功能状态与预后有关，因此， 抗氧化剂的辅助治疗将阻断心功能恶化，改善患者预后，丹参液治疗心 血管疾病会有广阔的前景。更多还原

【Abstract】 Background SM has special advantages in cardiovascular diseases treatment as Chinese conventional herb medicine, many animal experiment and some clinical study indicate that SM injection has acted on many periods in coronary heart disease, break off pathology progress, improve left ventricular diastolic function, the mechanism is mainly antioxidation, but there are few studies in human?s correlating the therapy effect with increased free radical injury and antioxidation, few studies in influence of left ventricular function, and even no studies in coronary heat diseases patients correlating oxidation and antioxidation with ultrosonic- cardiographic left function evaluations. Objectives We sough to study antioxidatant effect and influence on left ventricular function of patients with stable angina treated by SM injection. Methods Eighty patients were randomized to received either basic therapy or suppiemented with SM for 10 days. In addition to clinical evaluations, we measured markers of oxidative (MDA) and defense against oxidative stress (SOD,GSH-Px) and left diastolic and systolic function by UCG. Results The patients age, genda, drug intake, coexist disease are comparable in basic treatment groups and SM groups: 1.There was a significant difference of MDA, SOD, GSH-Px, SOD/MDA, ~\ MDA, A SOD, A GSH-Px, SM group has more improvement. P<0.05 or P<0.01. 5 2.There was a significant correlation between improvement of clinical syndrome, ECG (electric-cardiography) and those oxidant and antioxidant variable ,P<O.05. 3.There was a significant difference in diastolic function pre-post therapy such as IRP(isovolume relaxation phase), Ei(E area), P<O.05,had no influence in systolic fundtion. 4.There was significant correlation between improvement of diastolic function and clinical improvement, P<O.05 or P<O.Ol. 5.There was significant correlation between improvement of diastolic function and oxidant and antioxidant variables, respectively, P<O.O1,P<O.05. Conclusion: 1 .Lmprovement of clinical syndrome of patients with stable angina partly did rely on antioxidation at least. 2.Antioxidant supplement will prevent the evolution of cardiac decompensation and improve myocardia function or survival. SM has new prospective therapy function as Chinese medicine advantage更多还原