【作者】 施红；

【导师】 林求诚；

【作者基本信息】 福建中医学院 ， 中西医临床结合， 2000， 硕士

【摘要】 通过石斛合剂及达美康对6O例Ⅱ型糖尿病中医辨证属阴虚热盛和气阴两虚患者的疗效分析以及高血糖症造模动物的实验研究，初步观察该合剂的降血糖作用及对临床症状，血脂、血粘度等疗效以利开发应用。 动物实验采用肾上腺素和四氧嘧啶造模；临床观察采用辨病与辨证相结合的方法，将阴虚热盛，气阴两虚者分为正常组，石斛合剂治疗组和达美康对照组，观察治疗前后中医症候，血糖、血脂、血粘度等变化。实验结果表明：该合剂具有显著降低肾上腺素和四氧嘧啶造模动物的血糖（P＜0.001），使血糖恢复正常，其疗效优于降糖灵即苯乙胍（P＜0.02），类似于优降糖（P＞0.05），且无优降糖的低血糖副反应。临床疗效观察表明，治疗组与对照组降血糖显效率分别为63.3％、23.3％；总有效率为96.7％、73.3％，对Ⅱ型糖尿病综合显效率分别为：86.7％、43.3％，治疗组明显优于对照组（P均＜0.01）。 结论：石斛合剂不仅具有直接降低血糖作用，而且具有改善患者综合症状的作用，提示：石斛合剂或西药配合石斛合剂的疗效明显优于达美康或达美康配合其它类降糖药，该研究的结果为该药作为治疗Ⅱ型糖尿病的中药制剂奠定了基础，具开发应用的重要价值。更多还原

【Abstract】 Clinical and Experimental Studies on DendrobiumMixture in DiabetesModern Depatement, FuzhouFujian College of Traditional Chinese medicime (TCM)ShiHong[Abstract] : Analysing the effect on 60 cases of NIDDM of TCM differentiate belong to two types of Yin-deficiency and heat-overabundance (阴虚热盛)、deficiency of both vitalenergy and Yin (气阴两虚) by using Dendrobium Mixture (石斛合剂) contrast to using Diamicron (达美康) as well as animal experimental study on hyperglycohemic mice with Dendrobium Mixture (DM). We were to preliminary observing the DM’s effect of reducing the blood sugar of hygerglycemia and the treatment effect on climical symptoms and signs, and the change of lipid include triglyceride (TG), total cholesterol (TC), of blood viscosity et al, to enable the DM for further exploition and utilization.Animal experiment was used the methods of Adrenaline (肾上腺素) and Tetraoxypyrimidine (四氧嘧啶) inducing hyperglycocemia. Thus the clinical observation was used the method of combine differentation of disease (辨病) with differentiation of symptoms and signs (辨病) with above two types of people, they were divided into three groups. Normal group (people nondiabetics, 30 cases) : simple had DM. Curative group (people ill with NIDDM, 30 cases) : simple had DM or preserve former western medicine plus DM. Control group (people ill with NIDDM, 30 cases) : simple had Diamicron or Diamicron plus BG (双胍类降糖药). After one period of treatment we contrasted the effect of above three groups with change indexs of blood sugar, TG、TC, viscosity, clinical symptomsand signs.Animal experiment showed the DM was of remarkably reduce the blood sugar level of hyperglycemic mice with Adrenaline and Tetraoxypyrimidime inducing hyperglycemia (P<0.001) and return the blood sugar of above experimental diabetes mice to normal level. The DM decreasing blood sugar effection was superior to Phenformin (P<0.02). equal to Glyburide (P>0.05). but didn’t have the glycopenic reaction of GlyburideClinical study showed the notable effective rate of decreasing blood sugar in curative group and control group was 63.3%, 23.3% separately. The total effective rate of decreasing blood sugar in above two groups was 96.7%, 73.3% respectively. The curative group was notably superior to control group (P<0.01).Above studies demonstrated the DM not only had directly decreasd the level of blood sugar, but also had improved the clinical symptoms and signs ,decreased the over-abundance of TG, TC, as well as viscosity and lead those inedxes to normal level. The studies confirmed the DM or DM plus western medicine was superior to the Diamicron or Diamicron plus BG. The results of above studies had lay a foundation of DM as a pure TCM drug to cure the deabetes. And the DM do have an important value of exploition and application.更多还原