【作者】 缪趁；

【导师】 顾勤；

【作者基本信息】 南京中医药大学 ， 中医学， 2012， 硕士

【摘要】 研究目的：本课题旨在研究以理中汤为代表的温中补虚法治疗腹泻型肠易激综合征脾阳虚证的临床疗效。研究方法：理论研究部分,概述中医学对腹泻型肠易激综合征病名、病因病机、辨证治疗、实验研究概况和现代医学对本病的发病及治疗进展的认识。临床研究部分,根据相关标准进行临床研究设计,选择腹泻型肠易激综合征患者60例,随机分为两组,即理中汤治疗组(简称治疗组)30例和培菲康对照组(简称对照组)30例,采用问卷调查方式,观察并分析治疗前后各组证候积分、综合疗效及生存质量情况。研究结果：经统计学分析得出,治疗后两组患者中医证候总积分,具有极显著的差异(P<0.01),治疗组于治疗后中医证候总积分明显低于对照组,说明治疗组在改善中医证候上有显著的疗效。治疗后两组中医临床综合疗效存在显著性差异性(P<0.05),中药治疗组在临床综合疗效上优于西药对照组。治疗后,治疗组患者生存质量中焦虑不安(DP)、社会反应(SR)、健康忧虑(HW)、挑食(FA)及人际关系(RS)方面积分均有显著改善(P<0.05),对照组在HW和FA方面有显著改善(P<0.05)；治疗组在改善DP、SR方面疗效优于对照组(P<0.05)。结论：运用以理中汤为代表的温中补虚法治疗腹泻型肠易激综合征脾阳虚证患者,具有较为满意的临床疗效,并可使该类患者生存质量积分得到改善。更多还原

【Abstract】 Objective:To observe the effect of Lizhong decoction treating IBS-D of spleen-Yang deficiency syndrome with warming middle-Jiao and filling weakness method.Methods:In theoretical study part, the author summarized IBS-D from the following aspects:the name, the etiology and pathogenesis, the syndrome differentiation, the experiment studies, and the pathogenesis and the improvement of treating method in the opinion of modern medicine. In clinical study part,60patients who were diagnosed with IBS-D were randomly divided into two groups,30cases in treatment group treated with Lizhong decoction and30cases in control group treated with bifid triple viable capsule.To observe and analysis the syndrome integral,clinical effect and the quality of life preceding and after treatment by filling questionnaire survey.Results:The syndrome integral of two groups after treatment showed significant difference (P<0.05), which in treatment group was lower than that in control group, it showed TCM had certain therapeutic effect on the syndrome improvement. The clinical effect of two groups after treatment showed significant difference (P<0.05), the function of treatment group was obviously better than that of control group. After treatment, the integral of DP,SR,HW, FA,RS in treatment group had made a remarkable improvement(P<0.05), and HW, FA were significantly improved in control group, treatment group was better than control group in improving DR and SR.Conclution:Warming middle-Jiao and filling weakness method had a good clinical effect on the therapy of IBS-D of spleen-Yang deficiency syndrome, which can improve the quality of life.更多还原