【作者】 殷洁；

【导师】 张苏闽；

【作者基本信息】 南京中医药大学 ， 中医学， 2012， 硕士

【摘要】 目的：探讨直肠给药这类外治疗法治疗溃疡性直肠炎的临床疗效及应用优势,并将溃结灌肠液灌肠与柳氮磺吡啶栓纳肛这两种不同的直肠给药方法治疗溃疡性直肠炎的疗效做对比研究。方法：筛选并收录符合纳入标准的溃疡性直肠炎患者共30例,将患者随机分成两组,即灌肠组(实验组15例)和纳肛组(对照组15例),两组患者在年龄、性别方面的差异无统计学意义(P<0.05)。实验组给予溃结灌肠液保留灌肠治疗,每次取温热的溃结灌肠液80m1,用注射器推注保留灌肠,每晚睡前一次；对照组给予柳氮磺吡啶栓纳肛治疗,0.5克/枚,每次一枚,每日2次,午、晚睡前使用,两组患者均连续用药两周作为一个疗程,共3个疗程,观察并如实记录两组患者用药前后的临床表现、症状体征、血常规、粪常规、血沉、C-反应蛋白、肠镜检查等变化,判断疗效及有无不良反应。结果：两组患者在性别、年龄、病程方面无统计学差异(P>0.05),治疗前后各项观察指标的比较有统计学意义(P<0.05),而治疗后两组患者在大便次数、Sourtherland DAI评分、有效率方面的差异有统计学意义(P<0.05),治疗后两组患者在C-反应蛋白、血沉、内镜Baron评分方面无统计学差异(P>0.05)。结论：溃疡性直肠炎患者具有一定年龄分布规律,患者多集中在35-45岁年龄段；溃结灌肠液灌肠法较柳氮磺吡啶栓纳肛法在治疗溃疡性直肠炎方面的疗效更加显著,为临床治疗溃疡性直肠炎提供了一种疗效好、治愈率高的方法。意义：为临床合理用药提供参考。更多还原

【Abstract】 Objective:to study the clinical effectiveness and application advantages of the external therapy which be using treating ulcerative proctopathy by rectal administating, and contrast the clinical effectiveness of Ulcerative Colitis enema and Sulfasalazine suppository for treating ulcerative proctopathy.Methods:screening and included met inclusion criteria of ulcerative proctopathy patients30cases, than randomly divided those patients into two groups—enema group (the15cases) and anus group (the15cases), two groups of patients have no statistically significant differences in age and gender (P<0.05). Given the kuijieguanchang fluid retention enema treatment, filling80ml the fluid with syringe push note every time before sleeping; The control group give liu nitrogen pyridine anus sulfonylurea bolt treatment,0.5g/pieces, one piece a time, twice a day,take it late afternoon and before sleeping, two groups of patients were2weeks for use as a treatment, after three treatment, observe and faithfully record the clinical manifestation, symptoms and signs, routine blood, dung routine, blood sedimentation, c-reactive protein, endoscopic change of two groups of patients before and after treating, judge the effect and adverse reactions.Results:two groups of patients in the gender, age, duration without statistics difference (P≥0.05), the outcomes show statistically significant after treatment (P<0.05), and frequency of defecate, Sourtherland DAI scoreafter and the efficiency about the patients in two group have significant difference (P<0.05), the c-reactive protein, blood sedimentation, endoscopic Baron scoring have no statistical difference in the patients of two groups after treatment (P>0.05).Conclusion:ulcerative proctopathy patients have a certain age distribution, patients often focus on35-45years of age; kuijieguanchang fluid enema irrigation method is better than liu nitrogen pyridine anus sulfonylurea bolt method in treating ulcerative colitis straight. It provides a good treatment method for treating ulcerative proctopathy, and the method have the advantage on absorption effect and small side effects.Meaning:to provide reference for clinical rational drug using.更多还原