节点文献
商陆对肾病综合征水肿湿热证的临床治疗作用观察与分析
Effects and Analysis of Phytolacca Therapy on Damp-heat of Edema in Nephritic Syndrome
【作者】 戴思思；
【导师】 冯松杰；
【作者基本信息】 南京中医药大学 ， 中医内科学， 2012， 硕士
【摘要】 目的：本研究通过对两种剂量(常规剂量和小剂量)商陆治疗肾病综合征水肿湿热证的疗效、毒副作用及剂量与疗效相关性的观察,进行分析总结,为更好的继承和创新中医药事业做研究,以期更好的指导临床。方法：本研究将30例肾病综合征水肿湿热证的患者随机分为常规剂量商陆(8-10g)组15例,小剂量商陆(4-6g)组15例,所有患者均在西医基础治疗上(不包括利尿剂)服用含不同剂量商陆的中药煎剂,疗程为7天,观察患者治疗前后24小时尿量、体重、水肿轻重程度、大便等变化情况。采用SPSS17.0统计软件包进行统计学处理,计量资料用(X±S)表示,组内比较用配对t检验,组间比较用独立样本t检验；计数资料用X2检验。P<0.05为有统计学意义。结果：(1)常规剂量组总有效率46.7%,小剂量组总有效率60.0%,两组疗效无显著性差异。两组患者治疗前后其尿量、体重、水肿等疗效性指标经统计学分析亦无显著性差异。(2)两组均能有效改善患者的中医证候,但组间相比无统计学差异(P>0.05)。(3)两组病例治疗前后在安全性指标方面无显著性差异(P>0.05)。结论：常规剂量及小剂量商陆合四妙散治疗肾病综合征水肿湿热证,均能有效改善患者临床症状、体征,但二组均未能体现明显的攻逐作用,常规剂量及小剂量商陆用于肾病综合征水肿湿热证基本是安全的。
【Abstract】 Objetive:Observe the effects, side effect and dosages-effect relationship of two doses(conventional dose and small dose) Phytolacca therapy on Damp-heat of edema in nephritic syndrome, appraise to its validity and security, in order to guide the clinical treatment.Methods:In this study,30example patients with nephritic syndrome edema damp-heat are divided into2groups, in the ratio of1:1,15patients with conventional dose and15patients with small dose. Treatment for7days. Observe the24-hour urine, body weight, feces, edema grade, side effect before and after treatment. The statistics were treated by statistical package SPSS17.0. Measurement datas were described with mean±standard deviation (X±S). The main measurement datas before and after treatment was compared with matched-pairs t-test. comparison between groups use independent sample-t-test. Enumeration data were chi-square tested and P<0.05for statistical significance.Results:(1) The efficiency of conventional dose group is46.7%, the small dose60.0%. The two groups are no significant difference in efficacy.(2) In the two groups, the symptom score improved obviously, but have no significant differcnces(P>0.05).(3) The safety index before and after treatment have no significant difference both of the group (P>0.05).Conclusion:Both of the treatment of conventional dose and small dose can improve clinical symptoms and physical signs, but no significant differences in purgation and diuresis. The conventional dose and small dose of Phytolacca in treatment of nephritic syndrome is safe.