【作者】 唐文冰；

【导师】 林有坤；

【作者基本信息】 广西医科大学 ， 皮肤性病学， 2012， 硕士

【摘要】 目的：为了提高临床医生对新生儿红斑狼疮的认识,进一步提高新生儿红斑狼疮的诊疗质量。方法：对2例非临床红斑狼疮或干燥综合征患者所生的新生儿红斑狼疮患儿的临床病历资料进行分析总结,并结合相关文献讨论其发病病因、临床特点、组织病理学特征、诊断、鉴别诊断及治疗。结果：根据2例新生儿的皮疹特点,患儿及生母ANA(±)、抗ENA：抗Ro/SSA(+).抗La/SSB(+),以及皮肤病理改变,并与其它有类似I临床表现的皮肤病进行鉴别,诊断新生儿红斑狼疮成立。结论：新生儿狼疮临床上少见,非临床红斑狼疮或干燥综合征患者所生者更少见,容易误诊,但只要提高认识,根据典型的临床表现,结合母婴实验室检查,以及组织病理学改变,并经与相关疾病进行鉴别,可以确诊。更多还原

【Abstract】 Objective:In order to improve medical doctors to understanding neonatal lupus erythematosus, and further knowledge of diagnosis and treatment of neonatal lupus.Methods:Clinical data of two cases of neonatal lupus erythematosus born from mother who have no clinical features of lupus erythematosus and Sjogren syndrome were analyzed and related literatures associated with the causes, clinical manifestations, pathological changes, diagnosis and treatment were reviewed.Results:Clinical manifestation of the patient is typical; laboratory tests of both mother and infant:ANA(+), antiRo/SSA(+), antiRo/SSB(+); histopatholo-gy changes are fixed with connective tissue disease and diagnose as neonatal lupus erythematosus after distinguished form other related diseasesConclusion:Neonatal lupus erythematosus is rare, born by obvious clinical features of SLE and SS mother is more rare, easy to misdiagnose.But improve the knowledge of the NLE, can be maked exact diagnosis by characteristics of skin lesions, immuno-laboratory test of both mother and fetus and histopatho-logical changes after excluding the differential diagnosis.更多还原