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164例不同中医证型慢性乙型肝炎患者病理、肝纤四项的临床分析
Retrospective Study on Pathological Results, Four Results of Liver Fiber, and TCM Syndrome Type of 164 CHB Patients
【作者】 王宏峰；
【导师】 曾斌芳；
【作者基本信息】 新疆医科大学 ， 中医内科学， 2011， 硕士
【摘要】 目的:通过对慢性乙型肝炎患者中医证型与肝组织病理、肝纤四项的回顾性分析,为慢性乙型肝炎中医分型客观化提供依据。方法:通过对2009年度在新疆维吾尔自治区中医院就诊的慢性乙型肝炎患者中医证型、肝组织病理、肝纤四项的分布情况进行了回顾性调查,分析其特点及规律。结果:本研究在一定程度上客观地揭示了慢性乙肝患者的病机演变规律是一个从肝郁脾虚,肝郁气滞,肝胆湿热,肝郁血瘀的传变过程,病势由浅至深、病情由轻至重的传变过程。肝郁贯穿于疾病始终。血清III型前胶原(PC-III)、透明质酸(HA)、层粘蛋白(LN)和IV型胶原(IVC)对研究肝纤维化的程度有一定的临床价值。结论:从研究得出可以得出血清III型前胶原(PC-III)同肝穿病理契合度最高,可作为今后临床研究重点。肝纤四项及肝组织病理分级可为慢性乙肝辨证分型客观化提供一定参考依据。
【Abstract】 Objective: To provide evidence of objective types of chronic hepatitis B by analysis of TCM syndrome type, liver tissue pathology, and four results of liver fiber. Methods: We investigated the TCM syndrome type, liver tissue pathology, and four results of liver analyzed fiber of the chronic hepatitis B patients in Xinjiang Traditional Medicine Hospital, and analyzed the characteristics and patterns. Results: This study reveals the development pattern of patients with chronic hepatitis B to a certain extent:, from mild to heavy. ganyuwas found through the process. Type III serum collagen (PC - III) , hyaluronic acid (HA) , layer mucin (LN) and type IV collagen (IVC) were clinically valuable to the study. Conclusion:Type III serum collagen (PC-III) is highly matched up with liver biopsy pathological result, and could be clinical research focus in the future. Four results of liver fiber and liver tissue pathological classification could provide certain reference for the syndrome differentiation of chronic hepatitis B.