【作者】 陈烈；

【导师】 雷健；

【作者基本信息】 湖北中医药大学 ， 中医学， 2011， 硕士

【摘要】 目的：观察冠心通脉胶囊对冠心病心绞痛患者血清中的一氧化氮(NO)、超敏C反应蛋白(Hs-CRP)及内皮素(ET)的影响。明确冠心通脉胶囊对冠心病心绞痛的疗效,探讨其可能作用机制,为其临床应用提供科学依据。方法：将60患者按抽签法随机分成两组,治疗组在常规用药基础上加用冠心通脉胶囊,对照组则服用通心络胶囊,治疗观察一个疗程(4周)后,比较两组临床疗效,心电图改变,并分析治疗前后两组患者血中NO、ET、Hs-CRP的变化。结果：治疗组心电图有效病例24例,无效4例,总有效率达85.7%,而对照组有效病例27例,无效3例,总有效率90.0%,在心电图疗效上两组比较差异无统计学意义(p>0.05)；治疗组临床疗效有效病例26例,无效2例,总有效率达92.9%,而对照组有效病例28例,无效病例2例,总有效率达933%,临床疗效上两组间差异无统计学意义(P>0.05)。治疗组NO由治疗前(87.24±9.31)umol/l上升到(110.17±9.35)umol/l,治疗前后比较差异有统计学意义(P<0.05)；ET由治疗前(118.12±31.67)ng/1下降到(99.46±24.98)ng/1,前后比较差异有统计学意义(p<0.05)；Hs-CRP由治疗前(8.55±2.34)mg/1下降到(4.97±2.13)mg/1,前后比较差异有统计学意义(p<0.05)；对照组NO由治疗前(88.93±8.45)umol/l上升到(113.52±7,88)umol/l,治疗前后比较差异有统计学意义(P<0.05)；ET由治疗前(121.5±33.94)ng/1下降到(102.21±28.76)ng/1,前后比较差异有统计学意义(p<0.05); Hs-CRP由治疗前(8.61±2.18)mg/1下降到(5.34±2.37)mg/l,前后比较差异有统计学意义(p<0.05)；两组间治疗前后NO、ET、Hs-CRP比较差异无统计学意义(p>0.05)。结论：冠心通脉胶囊对冠心病心绞痛有一定疗效,其可能作用机制是通过促进NO的释放、降低ET及Hs-CRP的水平,对血管内皮功能的保护来实现,具体机制有待于进一步阐明。更多还原

【Abstract】 Objective:To observe the influence of Guanxintongai capsule on nitric oxide (NO)High sensitivity C-reactive protein(Hs-CRP) and Endothelin(ET) of patients who suffered angina pectoris of the disease of coronary heart disease and make clear the effects by treating with the Guanxintongmai capsule in order to explore the probably mechanisms, and give us some credible scientific basis for the clinical application.Methods:Sixty patients with angina pectoris were randomly divided into two groups:Treatment group(n=30) treated with guanxintongmai capsule and the control group (n=30) with tongxinluo capsule for four weeks. then we analyze the levels of ET/NO/hs-CRP between the patients.Results:Effective treatment of patients ECG observed in 24 cases, 4 cases, the total effective rate of 85.7%, while the control group,27 cases of effective cases and ineffective in 3 cases, the total efficiency of 90.0% Compared with this it has no Significant difference between two groups (p>0.05); Effective treatment of patients clinical binefis observed in 26cases,2 cases, the total effective rate of 92.9%, while the control group,28 cases of effective cases and ineffective in 2 cases, the total efficiency of 93.3% Compared with this it has no Significant difference between the two groups (p>0.05); NO by the treatment group before treatment (87.24±9.31)umol/l up to (110.17±9.35)umol/l, it has Significant difference between the two groups, ET from the before treatment (118.12±31.67)ng/l down to (99.46±24.98)ng/l, it has Significant difference between the two groups; Hs-CRP by the treatment (8.55±2.34)mg/l decreased to (4.97±2.13)mg/l, it has Significant difference between the two groups; but NO from the control group before treatment (88.93±8.45)umol/l up to (113.52±7.88)umol/l, it has Significant difference between the two groups; ET decreased from (121.5±33.94)ng/l down to (102.21±28.76)ng/l, it has Significant difference between the two groups; Hs-CRP by the treatment (8.61±2.18)mg/l decreased to (5.34±2.37)mg/l, it has Significant difference between the two groups;At last we found that the Indicators of two groups has its significant difference.Conclusion:Guanxintongmai capsule has significantly influence on NO, ET, Hs-CRP for protectioning of endothelial function.更多还原