【作者】 王瑜；

【导师】 陈艳； 王发省；

【作者基本信息】 新疆医科大学 ， 公共卫生， 2011， 硕士

【摘要】 目的：研究正电子发射断层显像术(Positron Emission Tomography, PET)诊断孤立性肺结节(Solitary Pulmonary Nodules, SPN)的灵敏度(Sen)和特异度(Spe)以及在SPN患者中的应用价值。方法：回顾分析近两年新疆维吾尔自治区人民医院收治疑似SPN并获得病理证实的患者189例,绘制SPN诊断试验交叉表,并计算PET诊断SPN的灵敏度和特异度等指标。比较非PET组和PET组的无效开胸率以及两组在良恶性SPN患者中的花费。结果：PET组患者最终确诊恶性肿瘤75例(39.68%),良性结节17例(8.99%)。PET阳性患者76例(40.21%),PET阴性患者16例(8.47%)。诊断SPN的灵敏度为0.97,特异度为0.83,阳性11以然比为5.71,阴性似然比为0.04,阳性预测值为0.96,阴性预测值为0.88,诊断符合率为0.95。PET组和非PET组在无效开胸率的比较x2=9.803,P=0.002,差别具有统计学意义。PET组和非PET组在恶性结节经过开胸治疗的总花费上比较t=8.2195,P=0.0000,差别具有统计学意义；PET组和非PET组在良性结节经过开胸治疗的总花费上比较t=7.6406,P=0.0000,差别具有统计学意义。结论：PET在诊断SPN中有较高的准确性、使用价值较高,并且可以显著降低孤立性肺结节患者的无效开胸率。更多还原

【Abstract】 Objective:Research for Positron emission tomography (Positron Emission Tomography, PET), Diagnose sensitivity (Sen) and specificity (Spe) of solitary pulmonary nodules (Solitary Pulmonary Nodules, SPN) and application value of SPN patients. Methods:Review and Analysis of the past two years, suspected of Xinjiang Uygur Autonomous Region People’s Hospital, received 189 cases of patients with pathologically confirmed, draw SPN diagnostic experiment crosstab, and calculate the sensitivity that PET diagnoses SPN and especially beacons like difference, etc. A little bit not the void of PET set and PET set opens chest rate and 2 sets in the payout in the good malignant SPN sufferer. Results:The PET set sufferer finally confirms a malignant tumor 75(39.68%), the positive knot is 17(8.99%).The male sufferer of PET is 76(40.21%),16(8.47%) of PET feminine gender sufferer. Diagnose SPN sensitivity to 0.97, especially difference for 0.83, masculine gender however compare to 5.71, feminine gender however compare to 0.04, masculine gender anticipation be worth to 0.96, feminine gender predicts to be worth to 0.88, diagnosis match to lead to 0.95.PET group and non-PET group open the compare of chest rate in the void=9.803,P=0.002, the difference has statistical meaning. PET group and non-PET group at the malignant knot has been opened the total payout of chest treatment top compare t=8.2195, P=0.0000, the difference has a statistical meaning. PET group and the non-PET group of benign nodules after thoracotomy in the treatment of the total cost To compare t= 7.6406, P=0.0000, statistically significant differences. Conclusion:PET at diagnose there is higher accuracy, value in use in SPN and can be significantly reduced invalid thoracotomy rate in patients with solitary pulmonary nodules.更多还原