节点文献
TF方案和FOLFOX6方案治疗晚期胃癌的临床观察
TF Regimen and FOLFOX6 Regimen on Advanced Gastric Carcinoma in Advanced Gastric Cancer
【作者】 彭媛媛;
【导师】 唐勇;
【作者基本信息】 新疆医科大学 , 肿瘤学, 2011, 硕士
【摘要】 目的:比较TF方案和FOLFOX6方案治疗晚期胃癌的疗效及不良反应。方法:回顾性分析我院54例经病理确诊的晚期胃癌患者。A组28例,采用TF化疗方案:多西他赛50mg/m2,d1;CF400 mg/m2,d1;5-FU40 mg/m2,dl,5-FU2400~3000mg/m2,CⅣ(46小时),每14天为一周期,B组26例,采用FOLFOX6方案化疗:L-OHP100 mg/m2,d1;CF400 mg/m2,d1;5.FU400 mg/m2,d1,5-FU 2400-3000 mg/m2,CⅣ(46小时),每14天为一周期,对两组的近期疗效、生活质量改善情况、总生存期、无疾病进展时间、不良反应进行比较。结果:A组和B组的有效率分别为46.40%和46.20%,差异无统计学意义(P=0.99)。A组和B组的无疾病进展时间分别为5.5月,差异无统计学意义(P=0.54)。中位生存时间分别8.0月和8.5月,差异无统计学意义(P=0.71),A组和B组的生活质量改善为64.3%和30.80%差异有统计学意义(P=0.04);两组主要不良反应白细胞减少、血红蛋白减少、恶心、呕吐、便秘等指标的差异具有显著性(P<0.05)。结论:TF方案和FOLFOX6方案在晚期胃癌的治疗方面近期疗效比较好,在不良反应以及生活质量改善情况等方面,TF方案优于FOLFOX6方案,具有更好的耐受性。
【Abstract】 Objective:To compare the efficacy and toxicity of TF regimen and FOLFOX6 regimen on advanced gastric carcinoma (AGG) in gastric cancer. Methods:Retrospective analysis of 54 cases confirmed by pathology in patients with advanced gastric cancer,28 patients in group A treated with DF regimen:Docetaxel 50mg/m2,d1;CF400mg/m2,d1;5-FU400mg/ m2,d1;5-FU2400-3000mg/m2,CⅣV(46h), were given, repeated every 14 days; 26 patients in group B treated with FOLFOX6 regimen:L-OHP100 mg/m2,d1;CF400mg/m2,d1; 5-FU400mg/m2,d1;5-FU2400-3000mg/m2,CⅣ(46h), were given, repeated every 14 days.The efficacy,Progression Free Survival(PFS),overall survival (OS) improvement of QOL and toxicity of the two regimens were analyzed. Results:The response rate (RR) of group A and B were 46.40%and 46.20%,Difference was statistically significant(p=0.99). The median PFS was 5.50months in group A and5.50months in group B(P=0.54).The median survival time was 8.00 months in group A and 8.50 months in group B,Difference was statistically significant(p=0.71).The improvement rate of QOL of A and B were 64.30%and 30.80%,Difference was statistically significant(P= 0.04). Major side effect of the two groups had significant deference (P<0.05). Conclusion:Both TF and FOLFOX6 regimens were effective in treating advanced gastric cancer in patients. TF regimen is better than FOLFOX6 regimen on the improvement of QOL and toxicities survivability.
【Key words】 Advanced gastric carcinoma; Chemotherapy; TF regimen; FOLFOX6 regimen;