【作者】 罗文苹；

【导师】 刘汉锋；

【作者基本信息】 广西医科大学 ， 肿瘤学， 2011， 硕士

【摘要】 目的通过回顾性分析研究三阴性乳腺癌的临床病理特点和复发转移生存情况,以期探讨三阴性乳腺癌的临床特点及预后情况。方法本文回顾性研究分析乳腺癌患者295例,其中三阴性乳腺癌45例,非三阴性乳腺癌250例,采用Cox多元回归分析及Kaplan—Meier法和卡方检验等统计学方法进行分析。结果三阴性乳腺癌占同期乳腺癌患者的15%,与同期非三阴乳腺癌比较,三阴乳腺癌患者诊断时肿瘤直径大,分期较晚,腋窝淋巴结转移率高,p53突变率高以及复发转移率高,转移部位以内脏及脑多见。与非三阴性乳腺癌比较,三阴组5年生存率及5年无疾病进展生存率较差(71.1%V84%,p=0.038<0.05;48.9%V73.2%,p=0.001<0.05)。单因素分析结果显示:三阴乳腺癌患者的预后与原发肿瘤直径大,分期较晚,淋巴结转移率高及p53突变有关。多因素分析显示:淋巴结转移情况和p53突变是影响三阴乳腺癌预后的独立因素。结论与非三阴乳腺癌比较:三阴乳腺癌具有就诊时肿瘤直径大,分期晚,腋窝淋巴结转移率高,p53突变率高等特点,三阴乳腺癌5年总生存率、5年无疾病进展生存率较差,复发转移率高,转移部位以内脏及脑多见。更多还原

【Abstract】 Objective The aim of this study was to analyze the Clinicalpathol- ogic charcteristics, metastasis, survival and Prognostic factors of Triple-negative breast cancer.Methods Clinicapathologic data of 295 patients , and 45 patients were Triple-negative breast cancer. The Clinicapathologic Charcteristics, recurrence and survival of the patients were Analyzed.Results 15% all of breast cancers was TNBC. Compared to The non-TNBC, TNBC had larger tumor size ,advanced pathologic stage, more lymph node metastasis at diagnosis, higher mutation rate of p53 and recurrence rate. The 5-year disease free survival (DFS)and overall survival of TNBC were 48.9% and 71.1%, respetively. Simple fator analysis showed that tumor size ,lymph node status, pathologic stage and the mutation of p53 were found to be correlated with OS. Multivariate cox regression showed that lymph node status and the mutation of p53 were the independent fators influencing the prognosis of TNBC.Conclusion TNBC was characteristic of larger tumor size, more lymph node metastasis at diagnosis, advanced pathologic stage, higher mutation rate of p53 and recurrence rate, shorter survival time compared to the non-TNBC . The lymph node status and the mutation of p53 were the independent fators influencing the prognosis of TNBC.更多还原