【作者】 陈锐；

【导师】 舒惠荃；

【作者基本信息】 成都中医药大学 ， 中西医结合临床， 2010， 硕士

【摘要】 目的：初步研究健脾益气,补肾固精法治疗慢性肾小球肾炎(脾肾气虚证)蛋白尿的安全性和有效性。方法：根据病例纳入标准,将符合脾肾气虚证的慢性肾小球肾炎蛋白尿患者52例随机分为两组,试验组27例,对照组25例。试验组服用健脾益肾汤,对照组服用金水宝胶囊,疗程均为2个月,根据治疗前后患者主要临床症状的积分和实验室检查结果进行统计学处理及疗效判定。结果：慢性肾小球肾炎蛋白尿疗效比较,全分析数据集(FAS)分析结果显示试验组对患者尿蛋白疗效的临床控制率为8.00%,控显率为52.0%,总有效率为80%。对照组分别为4.3%,17.4%,47.8%。符合方案集(PP)数据分析结果显示,试验组对患者尿蛋白疗效的临床控制率为8.70%,控显率为52.2%,总有效率为87.0%。对照组分别为5.00%,25.0%,55.0%。两组间进行比较,P<0.05,具有显著性差异。脾肾气虚中医证候疗效比较,FAS分析显示试验组对脾肾气虚证的临床愈显率为56.0%,总有效率为88.0%。对照组分别为26.1%,65.20%。PP分析显示试验组对脾肾气虚证的临床愈显率为60.8%,总有效率为95.65%。对照组分别为30.0%,75.0%。两组间进行比较,P<0.05,具有显著性差异。结论：健脾益气,补肾固精法是治疗慢性肾小球肾炎(脾肾气虚证)蛋白尿的有效方法之一,能较好的改善患者临床症状,减少蛋白尿,稳定肾功能。更多还原

【Abstract】 Objective:To research primarily the efficacy and safety of profit tonifying the spleen and kidney, controlling essence in teeat chronic glomerulonephritis proteinuria for Qi deficiency of spleen and kidney syndrome.Methods:According to case inclusion criteria,52 cases met the Qi deficiency of spleen and kidney syndrome in chronic glomerulonephritis patients were randomly divided into two groups, experimental group,27 cases,25 cases of the control group. Wetting test group taking Jianpiyishen Decoction, The control group taking JSBC, a course of 2 months. According to clinical symptoms before and after treatment in patients with major points and laboratory test results were statistically processed and therapeutic efficacy.Results:Comparative effects of chronic glomerulonephritis proteinuria, all of the analysis data set (FAS) showed that the experimental group on the clinical efficacy in patients with urinary protein control rate was 8.00%,52.0% were controlled, the total effective rate was 80%. Control group were 4.3%,17.4%,47.8%. Per Protocol Set (PP) data analysis showed that the experimental group on the clinical efficacy in patients with urinary protein control rate was 8.70%, control was 52.2%, total effective rate was 87.0%. Control group were 5.00%,25.0%,55.0%. Between the two groups, P <0.05, statistically significant difference. Qi deficiency of spleen and kidney syndrome Clinical comparison, FAS analysis showed that the experimental group on the spleen and kidney qi deficiency Syndrome markedly effective rate was 56.0%, total effective rate was 88.0%. Control group were 26.1%,65.20%. PP analysis showed that the experimental group on the Qi deficiency of spleen and kidney syndrome markedly effective rate was 60.8%, total effective rate was 95.65%. The control group were 30.0%,75.0%. Between the two groups, P<0.05, statistically significant difference.Conclusion:The treatment of tonifying the spleen and kidney, controlling essence on chronic glomerulonephritis can greatly improve clinical symptom of patents, reduce the proteinuria, stable renal function.更多还原