【作者】 苑志慧；

【导师】 张晓琳；

【作者基本信息】 黑龙江中医药大学 ， 中医学， 2010， 硕士

【摘要】 目的：评价香灵乳康颗粒治疗乳腺增生病(肝郁肾虚、痰凝血瘀证)的临床有效性及安全性,为进一步临床试验提供依据。方法：选择乳腺增生病患者60例,随机分为治疗组和对照组各30例。治疗组：给香灵乳康颗粒,1袋／次,3次/日,口服,连服2个月经周期,经期停药。对照组：给安慰剂,1袋／次,3次/日,口服,连服2个月经周期,经期停药。两组患者治疗均以一个月为一疗程,治疗两个疗程观察并统计疗效。结果：1.治疗组对乳腺增生病的总有效率为93.3%,对照组对乳腺增生病的总有效率为23.3%,治疗组明显优于对照组,两组疗效对比具有显著性差异(P<0.05)。2.治疗前后两组中医证候总积分组内比较,差异均有显著性意义(P<0.01),治疗后两组组间比较,有显著性差异(P<0.01),提示治疗组优于对照组,能很好的改善临床症状。3.治疗前后两组中医主症积分组内比较,差异均有显著性意义(P<0.05),治疗后两组组间比较,有显著性差异(P<0.01),提示治疗组能很好的改善乳房的主要症状,其效果明显优于对照组。4.治疗前后两组乳房肿块长径组内比较,差异均有显著性意义(P<0.01),治疗后两组组间比较,有显著性差异(P<0.01),提示治疗组对乳房肿块有很好的治疗作用,且效果明显优于对照组。5.治疗前后两组乳房疼痛天数组内比较,差异均有显著性意义(P<0.01),治疗后两组组间比较,有显著性差异(P<0.01),提示治疗组能很好的缓解乳房的疼痛,且明显优于对照组。结论：香灵乳康颗粒对乳腺增生病有较好的疏肝补肾、活血化瘀、化痰止痛、软坚散结的功能,在综合疗效及中医证候疗效上都明显优于对照组,可有效的缓解乳房的疼痛,缩小乳房肿块,并明显的改善患者伴随症状,无明显的毒副作用。更多还原

【Abstract】 Objective:to evaluate the treatment of xiangling rukang granules of mammary gland hyperplasia (stagnation of liver qi and kidney dificiency phlegm coagulation and blood stasis syndrome), the clinical efficacy and safety to provide basis for further clinical trials.Methods:Choose glandular hyperplasia with 60 cases were randomly divided into the treatment group and control group,30 cases of each. Treatment group:give xiangling rukang granules,1 bag/times,3/day, oral, take 2 menstrual cycle, menstrual withdrawal. Control:to placebo,1 bag/times,3/day, oral, take 2 menstrual cycle, menstrual withdrawal. Two groups of patients treated with a month for a period of two treatment, treatment and statistical line.Results:1.Treatment of disease of mammary gland hyperplasia of the total effective rate of mammary gland 93.3% group total effectiveness is sick, treatment group was better than control group, compared with significant difference (P< 0.05).2. Before and after the treatment of two groups of TCM syndrome, total points within the group are significant difference (P<0.01), after treatment, the comparison between the two groups, significant differences (P<0.01), train the treatment group than in control group, can be very good to improve clinical symptoms.3. Before and after the treatment of TCM ZhuZheng two groups within the group, integral significant difference (P<0.05), after treatment compared between two groups, have significant difference (P<0.01), train the treatment groups can improve breast symptoms, its effect is significantly better than placebo.4.Before and after the treatment of two groups breast lumps, length-diameter group were significant difference (P<0.01), after treatment compared between two groups, have significant difference (P<0.01), Clew therapy of breast lumps have very good therapeutic effect, and the effect was better than control.5. Before and after the treatment of two groups within the group breast ache days, significant difference (P<0.01), after treatment compared between two groups, have significant difference (P<0.01), train the treatment groups can alleviate the pain is very good, and breast cancer.Conelusion:Xiangling rukang granules of mammary gland hyperplasia is good to soothe the liver, nourish kidney, reduce phlegm and analgesic, resolving hard lump, in the overall effect and comprehensive functions on the effect of TCM syndrome than control group, and can effectively relieve the pain, shrink breast, breast lumps and noticeably improve patients with symptoms, no significant side effects.更多还原