【摘要】 目的制备非洛地平缓释片,并对其进行体外释放行为研究。方法以聚氧乙烯40氢化蓖麻油为增溶剂,羟丙基甲基纤维素（HPMC）和羟丙基纤维素（HPC）为缓释材料制备非洛地平缓释片。通过单因素对处方进行初步筛选,以正交试验筛选出最佳处方,考察自制制剂和参比制剂在不同释放介质中的释放行为,并进行f₂相似因子比较。结果选择HPC（JXF）用量为15%,HPMC（E50）用量为30%,HPMC（E10M）用量为10%时,制备的非洛地平缓释片与参比制剂在不同的释放介质中相似因子f₂均在50以上。结论自制非洛地平缓释片体外释放行为与参比制剂相似。更多还原

【Abstract】 Objective To prepare felodipine sustained-release tablets and determine its in vitro release. Methods Polyoxyethylene 40 hydrogenated castor oil was used as the solubilizing agent, and HPMC and HPC were used as the sustained-release materials to prepare felodipine sustained-release tablets. The prescriptions were screened by single factors, and the best prescriptions were screened by the orthogonal test. The release behaviors of self-made preparations and reference preparations in different release media were investigated, and f₂ similar factors were compared. Results When the selected amount of HPC（JXF） was 15%, HPMC（E50） dosage was30%, and HPMC（E10 M） dosage was 10%, the similar factor f₂ of the prepared felodipine sustained-release tablets and the reference preparation in different release media were above 50. Conclusion The in vitro release behaviors of self-made felodipine sustained-release tablets are similar to those of the reference preparation.更多还原