【摘要】 目的探讨红细胞分布宽度(RDW)与老年支气管扩张症急性加重期严重程度的相关性。方法收集2015年1月至2018年10月成都市第二人民医院呼吸与危重症医学科住院216例老年支气管扩张症急性期加重期患者的病历资料。用支气管扩张严重度指数(BSI)对老年支气管扩张急性加重期病情严重度进行评估,将患者分为低危、中危和高危三组。收集同期50例老年体检者为健康对照组。记录BSI、RDW、降钙素原(PCT)、中性粒细胞百分比(NEU%)和C反应蛋白(CRP)水平。用Spearman相关性分析指标间的相关关系。通过一般线性回归构建方程,计算RDW的阈值,用多元线性回归分析BSI评分的影响因素。结果危险度分层越高,BSI评分越高,RDW、PCT、NEU%和CRP值也越高。RDW与PCT、NEU%、CRP呈正相关(r值分别为0.425、0.311、0.177,均P<0.05)。BSI评分与RDW、PCT、NEU%、CRP呈正相关(r值分别为0.425、0.394、0.650、0.578,均P<0.05)。RDW的阈值分别为11.45%、14.03%。多元线性回归分析显示RDW、PCT、NEU%、CRP均是BSI评分的影响因素,解释了BSI评分变异率的52.3%。结论 RDW与老年支气管扩张症急性加重期病情严重程度有关,可以预测老年支气管扩张症急性加重期严重程度。更多还原

【Abstract】 Objective To investigate the relationship between the red blood cell distribution width(RDW) and the severity of acute exacerbation of bronchiectasis in elderly patients. Methods The clinical data of 216 elderly patients with acute exacerbation of bronchiectasis admitted from January 2015 to October of 2018 were analyzed retrospectively.The severity of acute exacerbation of bronchiectasis in the elderly was evaluated by bronchiectasis severity index(BSI)score. Meanwhile, 50 elderly people receiving qualified medical examination were collected as a healthy control group in the same period. The distributions of BSI score, RDW, procalcitonin(PCT), neutrophil percentage(NEU%) and C-reactive protein(CRP) were described in the patients with different risk degree. The severity of acute exacerbation of bronchiectasis in the elderly was evaluated by BSI. The patients were divided into three groups by BSI score: a low risk group, a middle risk group, and a high risk group. The indexes were described including the distribution of stratified BSI score, RDW, PCT, NEU%, CRP at different risk levels. The correlation of each index was analyzed by Spearman correlation. The threshold value of RDW was calculated by general linear regression, and the influencing factors of BSI score were analyzed by multivariate linear regression analysis. Results The higher the risk stratification, the higher the BSI score, RDW, PCT, NEU% and CRP were. RDW was positively correlated with PCT, NEU% and CRP(r values were0.425, 0.311, 0.177, respectively, P<0.05). BSI score was positively correlated with RDW, PCT, NEU%, and CRP(r values were 0.425, 0.394, 0.650, 0.578, respectively, P<0.05). RDW was positively correlated with PSI score(r=0.425, P<0.05). The thresholds of RDW were 11.45% and 14.03%. Multiple linear regression showed that RDW, PCT, NEU% and CRP were all influential factors of BSI score and explained 52.3% of the total mutation rate. Conclusion RDW is related to the severity of acute exacerbation of bronchiectasis in the elderly, and can predict the severity of acute exacerbation of bronchiectasis in the elderly.更多还原