节点文献
Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling
【摘要】 Many key cellular functions are regulated by the interplay of three distinct cytoskeletal networks, made of actin filaments,microtubules, and intermediate filaments(IFs), which is a hitherto poorly investigated area of research. However, there are growing evidence in the last few years showing that the IFs cooperate with actin filaments to exhibit strongly coupled functions.This review recapitulates our current knowledge on how the crosstalk between IFs and actin filaments modulates the migration properties, mechano-responsiveness and signaling transduction of cells, from both biophysical and biochemical point of view.
【Abstract】 Many key cellular functions are regulated by the interplay of three distinct cytoskeletal networks, made of actin filaments,microtubules, and intermediate filaments(IFs), which is a hitherto poorly investigated area of research. However, there are growing evidence in the last few years showing that the IFs cooperate with actin filaments to exhibit strongly coupled functions.This review recapitulates our current knowledge on how the crosstalk between IFs and actin filaments modulates the migration properties, mechano-responsiveness and signaling transduction of cells, from both biophysical and biochemical point of view.
【Key words】 intermediate filaments; actin; cytoskeletal interaction; cell migration; signaling pathway; cell mechanosensing;
- 【文献出处】 Science China(Life Sciences) ,中国科学:生命科学(英文版) , 编辑部邮箱 ,2019年10期
- 【分类号】Q25
- 【网络出版时间】2019-05-16 11:23
- 【被引频次】2
- 【下载频次】19