【作者】 李文鹏；

【导师】 江华； 吉永华； 林子豪； 袁相斌； 赵耀忠； 朱晓海；

【作者基本信息】 第二军医大学 ， 外科学， 2007， 博士

【摘要】 本研究旨在探讨再造阴茎感觉功能重建的有效方法及机制。实验以家兔为研究对象,首先运用电生理方法明确家兔阴茎皮肤感觉神经躯体纤维来源的分布规律,以此为基础,建立游离隐神经移植与阴茎背神经吻接后植入腹壁浅血管蒂皮瓣再造阴茎的动物模型,通过神经单纤维放电及神经源性血浆外渗方法,对再造阴茎感觉功能恢复情况进行观察。结果证实:①家兔阴茎皮肤感觉神经躯体纤维主要来源于S2-S3脊神经。②游离隐神经移植与阴茎背神经端端吻合植入以腹壁浅血管蒂皮瓣再造的阴茎,可以获得良好的感觉神经再生,感受器重新获得神经再支配,植入神经能够恢复再造阴茎的感觉功能。该研究结果为临床上重建再造阴茎的感觉功能提供了实验基础和理论依据。更多还原

【Abstract】 The purpose of this study was to investigate the possibility and mechanism of sensory restoration of the reconstructed penis and to explore a new surgical technique to improve the postoperative sensory function in phallic reconstruction. Firstly, Electrophysiological method was used to definitude the segmental distribution of the origin of the somatic fibers in the phallic sensory nerves of rabbits. Sensory nerve implantation was applied to establish the animal model of sensory restoration in phallic reconstruction, in which one lateral saphenous nerve graft was dissected as the donor nerve and anastomosed to one lateral dorsal nerve of the rabbit’s penis by end-to-end, and subsequently embedded in a superficial epigastric faciovascular pedicle flap for phalloplasty. Then the process of sensory recovery and nerve regeneration was evaluated by single nerve fiber recording and neugenic plasma extravasation method. Results showed that: 1) The rabbit’s sensory nerve fibers of the penis are origined from S2,S3 spinal nerves. 2) The new technique of phalloplasty established in this study can regenerate functional nerve and recover the sensory function of the reconstructed penis to a certain extent. These findings can provide theoretic and experimental basis for its clinical application to fulfill the sensory restoration of the reconstructed penis.更多还原