【作者】 张翔；

【导师】 李玉宝；

【作者基本信息】 四川大学 ， 生物医学工程， 2006， 博士

【摘要】 由于羟基磷灰石(Hydroxyapatite，HA，化学式为Ca₁₀（PO₄）₆（OH）₂)具有与人骨中主要无机矿物相相似的化学组成和结构，多年来一直被用作整形外科和牙科的植入材料。羟基磷灰石能诱导新骨的形成，并能与周围骨组织形成牢固的键合。然而，羟基磷灰石的低断裂强度，限制了它不能用作承重部位的骨修复材料。因此，开发和研制具有良好的力学性能和优异的生物活性与生物相容性的复合生物材料，以满足人体硬组织修复的需要，一直是生物医学工程领域研究的热点和难点问题。对于生物活性复合材料而言，常常是采用常规的塑料加工工艺，将生物陶瓷用来增强聚合物基体来制备。 纳米羟基磷灰石（Nano-hydroxyapatite，n-HA）增强聚酰胺66（Polyamide 66，PA66）复合材料（n-HA／PA66）是李玉宝等人近年来研发的一种新型的，可用于承重部位骨修复的复合生物材料。该复合材料中，羟基磷灰石可以以纳米尺寸分布在聚合物基体中，且羟基磷灰石的含量可达到65wt％。n-HA含量为62.5wt％的该复合材料的弯曲强度，拉伸强度和压缩强度分别可达到95，79和117MPa，而人骨的弯曲强度，拉伸强度和压缩强度分别80-100，60-120，50-140MPa，由此可见这些结果与人骨的力学性能很接近。此外，该复合材料的弹性模量为5.6GPa，也在自然骨的弹性模量（3-25GPa）范围之内。而其它一些生物材料，如生物陶瓷和更多还原

【Abstract】 Hydroxyapatite (HA, Ca₁₀（PO₄）₆（OH）₂) has been used for orthopedic/dental implants by its similar chemical composition and structure to the mineral phase of human bone, and it can promote sufficient new bone formation for the firm attachment of juxtaposed bone. However, duing to low fracture toughness, HA cannot serve as a bulk implant material under the high physiological loading condition. Therefore, development of biocomposites with good mechanical property, excellent bioactivity and biocompatibility similar to natural bone to meet the need of hard tissue repair has been a hot topic for over thirty years. To obtain an advanced mechanical performance of the bioactive composite, bioceramic particles were usually incorporated into the polymer matrix using conventional plastics processing technology.Nano hydroxyapatite （n-HA） reinforced polyamide 66 （PA66） （n-HA/PA66） biocomposites for load bearing bone repair were firstly prepared by a group leaded by Yubao Li. In the composite, HA crystals can keep their nano grade dispersion in the PA66 matrix and the content of n-HA can reach 65wt%. The bending strength, tensile strength and compressive strength of the composite with 64.25 wt% n-HA are 95, 79 and 117MPa, respectively, which are close to the natural bone （80-100, 60-120, 50-140MPa separately）, and the elastic modulus of this composite is 5.6GPa. However, the elastic modulus of bioceramics and medical metals are much higher （70-300GPa） than that of the natural bone （3-25GPa） and thus often cause stress stimulation or shielding effect, resulting in bone resorption and loosening of implants. Therefore, the mechanical更多还原