【作者】 樊昕；

【导师】 刘玉峰； 王刚；

【作者基本信息】 第四军医大学 ， 皮肤病与性病学， 2006， 博士

【摘要】 银屑病(Psoriasis)是一种病情顽固、易反复、治疗困难的常见皮肤病，严重影响着大约1-3％的世界人口的日常生活和心理健康。尽管其确切病因尚不完全清楚，但目前越来越多的证据表明，CD4(+)T细胞的活化是银屑病免疫学发病机制的中心环节。近年来关于其发病机制比较一致的观点是：银屑病的发病有其自身的遗传因素，在受到外界环境的影响后(包括感染、精神等因素)就会促使T细胞及角质形成细胞释放各种细胞因子，引起角质形成细胞的高度增殖及各种炎细胞的浸润，最终表现出银屑病特有的临床及病理特征。白细胞介素18(interleukin-18，IL-18)是一种重要的炎症前因子，主要参与Th1反应，可以介导免疫细胞进入组织而具有潜在的免疫调节作用。目前对于银屑病发病中效应机制的观点已经有了转变，现在认为局部皮损中各种免疫活性细胞、细胞因子和趋化因子及其受体组成的网络引发了一系列相互关联的作用，最更多还原

【Abstract】 Psoriasis is a common dermatological disorder, affecting approximately 1% to 3% of the general population. Although the pathogenesis of the disease has not been definitively understood, recent evidence suggests that activated CD4-positive helper T-lymphocytes of the Thl phenotype play an important role in the progression of psoriasis. The pathogenesis of psoriasis is linked to the activation of several types of leucocytes that control cellular immunity, and to a T-cell-dependent inflammatory process in skin that accelerates the growth of epidermal and vascular cells in psoriasis lesions. The most important processes in immunological activation are Langerhans and T cell activation, differentiation and expression of type 1 T (Thl) cells, selective trafficking of activated T cells to skin, and induction of an inflammatory cytokine and chemokine cascade in skin lesions. Psoriasis is associated with an overexpression of pro-inflammatory cytokines produced by Thl cells and a relative underexpression of Th2 cytokines. The Thl differentiation was found in both lesional areas and in the peripheral blood, although the high production of Thl cytokines or low production of Th2 cytokines is not determined by a genotype at this time. Interleukin-18 (IL-18), also called interferon-gamma (IFN- γ )-inducing factor, is a novel cytokine that plays an important role in the Thl response and a potent role in immunoregulation by更多还原