【作者】 赵惠；

【导师】 孙忠人；

【作者基本信息】 黑龙江中医药大学 ， 针灸推拿学， 2003， 博士

【摘要】 本课题以原络通经针法联合都可喜为治疗手段，设单纯都可喜为对照组，采用国际公认的诊断标准和客观的疗效标准以及多种神经心理测试量表，对66例血管性痴呆患者进行了比较系统、客观、全面的评价。结果表明：原络通经针法联合都可喜能够提高血管性痴呆患者MMSE、HDS-R的评分，改善ADL及中医征候评分，优于对照组（P＜0.05），临床总有效率为85.29％；还能够提高血浆中SS、AVP含量（P＜0.01）；使血管性痴呆患者P₃₀₀潜伏期缩短（P＜0.01），波幅增高（P＜0.05）；同时还发现血管性痴呆患者与正常老年人相比血浆中SS、AVP含量降低，P₃₀₀潜伏期延长，且与认知功能损害的严重程度相关。血浆中SS、AVP含量及事件相关电位P₃₀₀的测定，可作为VD患者认知功能及疗效评价的一项客观指标。 以上结果在一定程度上说明：原络通经针法联合都可喜治疗血管性痴呆疗效肯定，可改善患者的智能水平，恢复生活自理能力，调节患者血浆中SS、AVP含量，提高大脑皮层的兴奋性，促进患者学习、记忆等能力的恢复，疗效均优于单纯都可喜治疗组，并且痴呆程度越轻，疗效越好。原络通经针法是一种积极有效的血管性痴呆的治疗方法。更多还原

【Abstract】 In the present study, the combination of "Yuanluo Tongjing" method and duxil was used as the theraphy. The only duxil was used for control group. Neuropsychology testing chart and the internationally recognized criteria for diagnosis and effectiveness were adoped to evaluate 66 cases of vascular dementia (VD)patients systematacially, objectively and allsidely . The result showed that after treatment, MMSE scores , HDS-R scores , ADL and the symptom scores of TCM increased in comparison with the control group(P<0. 05). The total effective rate was 85.29%. The content of SS and AVP in blood plasma was improved(P<0.01). The P300 peak latency of VD patients was shortened(P<0. 01), whereas the amplitude was heightened(P<0. 05). In the meantime, it also showed that the content of SS and AVP in blood plasma of VD patients was lower than that of healthy and the P300 peak latency was prolonged, both of which were correlated with the severity of cognitive impairment. Measuring the content of SS, AVP and event-related potential P300 can be used as an objective parameters to evaluate the cognitive function and the therapeutic effect.The above results show that by treated VD patients with the combination of "Yuanluo Tongjing" acupuncture method and duxil, the therapeutic effect is affirmative. This method can improve the intellectual level of VD patients, resume the activity of daily living modulate the content of SS and AVP in blood plasma, enhance the excitability of cerebral cortex, promote the ability of learning and memorizing to recover, especially for the dementia which is not serious.It is a active and effective theraphy.更多还原