【作者】 高延娥；

【导师】 王静波；

【作者基本信息】 山东中医药大学 ， 中医五官科学， 2010， 博士

【摘要】 目的：用益气养阴明目开窍法治疗中晚期青光眼,并探讨其稳定眼压及视神经保护的作用机制。方法：1.实验研究：用益阴明目合剂给高眼压大鼠灌胃,检测其对高眼压大鼠血浆内皮素(endothelin, ET)、一氧化氮(nitrous oxide, NO)、视网膜超氧化物歧化酶(superoxide dismutase, SOD)、丙二醛(maleic dialdehyde, MDA)和谷氨酸(glutamic acid, Glu)的影响。2.临床研究：用益阴明目合剂治疗中晚期青光眼,通过治疗前后视力、视野、眼压的比较,总结和评价其疗效。结果：1.益阴明目合剂能有效提高急性高眼压大鼠视网膜中SOD活性,降低MDA、Glu含量,降低血浆ET和NO含量。2.益阴明目合剂治疗中晚期青光眼效果显著,总有效率为94.87%。结论：1.益阴明目合剂治疗中晚期青光眼疗效确切；2.益阴明目合剂可能通过清除自由基,增强耐缺氧能力,改善微循环,抑制谷氨酸的释放、降低内皮素含量等作用而起到稳定眼压和视神经保护的作用。更多还原

【Abstract】 Objective:To treat the glaucoma in middle and advanced stage with the method of YiQiYangYinKaiQiao and to study the mechanism of stabilizing the intraocular pressure and protecting the optic nerve with it.Methods:1.Experimental study:The plasma ET,NO,retinal SOD,MDA and Glu of the acute high intraocular pressure rats that treated with Yi Yin Ming Mu mixture were observed.2. Clinical study:The clinical therapeutic effect was observed by means of comparing the changes of visual acuity, visual field and intraocular pressure, before and after treatment.Results:1.Yi Yin Ming Mu mixture can effectively improve the activity of SOD, reduce the content of MDA, Glu, ET and NO of the acute high intraocular pressure rats.2. The curative effect of Yi Yin Ming Mu mixture in treatment of glaucoma in middle and advanced stage is obvious, with a total effective rate was 94.87%. Conclusion:l.The therapeutic effect of Yi Yin Ming Mu mixture in treatment of the patients with glaucoma in middle and advanced stage is identified.2.Yi Yin Ming Mu mixture can stablize the intraocular pressure and protect the optic nerve probably through clearing free radical, improving the anoxia tolerance, modifying microcirculation, restraining the releasing of Glu and reducing the content of ET.更多还原