【作者】 李保端；

【导师】 杨晓红；

【作者基本信息】 新疆医科大学 ， 内科学， 2010， 硕士

【摘要】 目的:通过对本院确诊的肺血栓栓塞症(Pulmonary thromboembolism, PTE;)患者蛋白C活性(activity protein C, APC)分析,了解蛋白C活性与年龄的关系,探讨其随着年龄的增加蛋白C活性的变化,及其在不同性别、民族之间的差异。方法:采用回顾性分析的方法对2006年1月至2009年12月的临床确诊的110例肺栓塞患者的临床资料进行分析,了解蛋白C活性与年龄的相关性,随着年龄增加的变化。按年龄大于60岁和年龄小于60岁及不同性别、民族分组,了解两组之间蛋白C活性水平、蛋白C活性降低发生率的差异。结果:1.110例PTE患者中男性72例、女性38例,年龄呈正偏态分布,整体中位数为61岁;最小年龄21岁,最大年龄82岁;男性年龄中位数65岁,最小年龄21岁,最大年龄82岁;女性年龄中位数61岁,最小年龄28岁,最大年龄72岁,秩和检验两组发病年龄比较无差异(P>0.05)。2.PTE患者PC缺乏的发生率为26.4%,随着年龄的增加蛋白C活性平均水平呈逐渐下降趋势,相关系数为-0.041,P=0.668,无线性相关性。年龄大于60岁的蛋白C活性降低的发生率明显高于年龄小于60岁的PTE患者,差异具有统计学意义(P<0.05)。3.蛋白C活性水平在男、女的中位数分别为83.0%、86.0%;两组蛋白C活性比较无统计学意义(P>0.05)。蛋白C活性降低分别为:男性正常55例,降低17例;女性正常26例,降低12例;两组比较蛋白C活性降低发生率无统计学意义(P>0.05)。4.肺血栓栓塞症患者汉族69例,维族41例,蛋白C活性水平的中位数分别为:汉族84.0%;维族83.4%,两组差异无统计学意义(P>0.05)。蛋白C活性降低分别为:汉族正常48例,降低21例;维族正常33例,降低8例,维汉两民族比较蛋白C活性降低的发生率无统计学意义(P>0.05)。结论:1.蛋白C活性平均水平随着年龄的增加呈逐渐下降的趋势,但是无线性相关性。2.年龄大于60岁的患者蛋白C活性降低的发生率明显高于年龄小于60岁的PTE患者。3.蛋白C活性水平、蛋白C活性降低的发生率在男女之间无差别。4.蛋白C活性水平、蛋白C活性降低的发生率在维吾尔族、汉族之间无差别。更多还原

【Abstract】 Objective: The analysis of activity protein C to patients with pulmonary thromboebolism (to call for short name pulmonary thromboebolism PTE) diagnosed in the hospital. The aim is to explore the change of APC with the age, and the difference between different nations, genders. Methods: Clinical data of 110 patients with PTE between January of 2006 and December of 2009 is analyzed retrospectively. The aim is to explore the relativity between APC and age, and the change of APC with the rising of age. The different level of protein C and the reduction of protein C between two groups are beyond 60 years and below 60 years. The second aim is to find the difference between the level of protein C and the reduction of protein C in different genders, nations. Results: 1. There are 72 men and 38 women among 110 cases, and their ages appear positive skewness distribution. The median is 61 years. The smallest age is 21 years old, and the oldest age is 82 years in the data. The median of age about men is 65 years, and the smallest and the oldest age is 21 years and 82 years respectively. The median of age about women is 62 years, and the smallest and the oldest age is 28 years and 72 years respectively. There is no difference between the ages of two groups. The absent incidence rate of active protein C in 60 years eld is obviously higher than the younger. 2. The incidence rate to absence of protein C in PTE patients is 26.4%. The average level of active protein C appears decreasing along with the patients’age increase, and the result shows to be no difference. The coefficient correlation is -0.041, P=0.668 which shows there is no linear correlation. 3. The median of active protein C among men and women is 83.0% and 86.0% respectively. The compared result of two groups is P>0.05 showing that there is no difference. The absent incidence rate of active protein C is the below. There are 55 men with normal level of protein C, and 17 men with low level of protein C. 26 women with normal level of protein C and 12 women with low level of protein C. The result is P>0.05, and there is on statistical significance between two groups. 4. There are 69 cases of Han nationality and 41 cases of Uygur nationality. The result compared to the ages of two groups is not significant (P>0.05). The median of active protein C is 84.0% and 83.4% respectively among the Han nationality and the Uygur nationality. Absence of active protein C is 48 cases of Han nationality with normal level of protein C, 21 cases with low level; 33 cases of Uygur nationality with normal level of protein C, and 8 cases with low level of protein C respectively. There is no evident statistical significance (P>0.05). Conclusion: 1. The average level of protein C is decreasing with the age becoming older. But there is no linear correlation. 2. The absent incidence rate of active protein C in 60 years eld is obviously higher than the younger. 3.There is no evident difference in the level of APC and absent incidence rate of active protein C between different genders. 4. The average level of protein C and absent incidence rate of active protein C has on difference in Han nationality and the Uygur nationality.更多还原