【作者】 田淑妮；

【导师】 伊力多斯·艾合他木夫；

【作者基本信息】 新疆医科大学 ， 内科学， 2010， 硕士

【摘要】 目的:探讨2型糖尿病患者动脉粥样硬化(AS)与血清中铁蛋白(SF)水平之间的关系,为糖尿病动脉粥样硬化的临床防治提供理论依据。方法:测定血清铁蛋白水平及行颈动脉B超,以168例2型糖尿病患者为研究对象,将T2DM中有颈动脉粥样硬化(CA)的无颈动脉粥样硬化的分为两组,分析血清SF与颈动脉粥样硬化的相关性,并分别比较两组间各相关指标有无差异,进行多因素Logistic回归分析。结果:1.颈动脉病变组SF水平显著高于颈动脉正常组(p<0.05)。2.相关分析通过Spearman相关分析,结果表明,T2DM患者血SF水平分别与颈动脉粥样硬化、甘油三酯、糖化血红蛋白、胰岛素抵抗指数等呈显著正相关(p<0.05),与高密度脂蛋白呈显著负相关(p<0.05)。与族别、体重指数、尿酸、总胆固醇、低密度脂蛋白等无显著相关性。对颈动脉粥样硬化的各主要危险因素行Logistic回归分析显示,血清铁蛋白、甘油三酯、高密度脂蛋白、糖化血红蛋白进入回归方程。结论:SF的升高可能预示着2型糖尿病动脉粥样硬化的发展。更多还原

【Abstract】 Objective:Approach the relationship between type 2 diabetes mellitus artherosclerosis and serum ferritin(SF), to provide clinic prevention theory for type 2 diabetes mellitus artherosclerosis. Methods: Determined SF and consummated type-B ultrasonic of carotid arteries,use 168 type 2 diabetes mellitus patients to study. The 168 patients were allocated into two groups: carotid atherosclerosis and carotid arteries normal. Analyzing the correlation between SF and carotid atherosclerosis, comparised the index between the two groups,then use mu1tiple linear regression. Results:1. SF levels of type 2 diabetic patients with arteria carotis defect were significantly higher than those of patients without arteriaearotis defect(p<0.05).2. Spearman correlation analysis showed that SF levels was significantly positively correlated with CA、TG、HbA1c、HOMA-IR(p<0.05),SF levels was significantly negatively correlated with HDL-C(p<0.05), there was no significantly correlated with series、BMI、UA、TC and LDL-C,mu1tiple linear regression showed SF、TG、HDL-C and HbA1c entered the equation. Conclusions: Elevated SF levels maybe an effective indicator of development in type 2 diabetes artherosclerosis.更多还原