【作者】 付晓乐；

【导师】 安冬青；

【作者基本信息】 新疆医科大学 ， 中医内科学， 2010， 硕士

【摘要】 目的:通过对血浆内皮素(ET)、血浆血栓调节蛋白(TM)的含量变化观察,初步探讨冠心病秽浊痰阻证与血管内皮损伤之间的关系,进一步为制定冠心病秽浊痰阻证的诊断标准提供微观的客观依据,使冠心病秽浊痰阻证的诊断趋于客观化。方法:选取冠心病秽浊痰阻证84例、冠心病非秽浊痰阻证88例、健康对照组78例;观察三组一般资料及血浆内皮素(ET)、血浆血栓调节蛋白(TM)的含量的变化。结果:1)血浆ET含量的比较:与健康对照组相比,冠心病秽浊痰阻证组、非秽浊痰阻证组患者血浆ET含量均明显增高,差异有统计学意义(P<0.01);冠心病秽浊痰阻证组血浆ET含量与非秽浊痰阻证组比较,差异亦有统计学意义(P<0.05);2)血浆TM含量的比较:与健康对照组相比,冠心病秽浊痰阻证组、非秽浊痰阻证组患者血浆TM含量增高,差异均有统计学意义(P<0.01);冠心病秽浊痰阻证组血浆TM含量高于非秽浊痰阻证组(P<0.05)。结论:冠心病秽浊痰阻证的实质是秽浊痰湿阻于脉道,闭阻气血,而致痰瘀内生,微观表现是ET、TM水平升高,表明冠心病秽浊痰阻证与非秽浊痰阻证相比,其血管内皮损伤更为明显。血浆ET、TM可以作为冠心病秽浊痰阻证中医辨证的客观依据。更多还原

【Abstract】 Objective:The aim of this study is to investigate the plasma level of Endothelin(ET) and Thrombomodulin(TM), so as to explore the relationship between CHD HuiZhuoT- anzhu Syndrome and endothelium dysfunction, provide the microcosmic objective basis for working out the diagnose standard for the coronary heart disease HuiZhuoTanZu Syndrome, in order to make its diagnose tend being externalization. Methods: A total of 172 samples were obtained from 84 cases of CHD huizhuotanzu syndrome and 88 cases of CHD non-huizhuotanzu syndrome, 78 cases of normal controls, then observe and analyses the general data and the plasma level of ET、TM among three groups. Results: 1) Comparison of plasma ET: Compared with normal controls, the lever of ET of CHD HuiZhuoTanzhu Syndrome group and non-HuiZhuoTanzhu Syndrome group are significantly higher, the difference is statistically significant (P<0.01 ); between CHD HuiZhuoTanzhu Syndrome group and the non- HuiZhuoTanzhu Syndrome group, there is a significant difference in the lever of ET (P<0.05). 2) Plasma TM level in comparison: the lever of TM in CHD HuiZhuoTanzhu Syndrome group and non- HuiZhuoTanzhu Syndrome group are higher than healthy control group, the difference is significant (P<0.01), and the lever of TM in CHD HuiZhuoTanzhu Syndrome group is higher than non-HuiZhuoTanzhu Syndrome group (P<0.05). Conclusion:The essence of CHD HuiZhuoTanZu syndrome is huizhuo resistance in the veins Road, closed resistance blood,result in phlegm and blood stagnate in the body, the microcosmic performance is that the levers of ET and TM has increased, there are obvious endothelium dysfunction state in the CHD HuiZhuoTanZu syndrome than non-HuiZhuoTanZu syndrome.The increasing contents of ET、TM can help us to differentiate the CHD HuiZhuoTanZu syndr- omee and non-HuiZhuoTanZu syndrome.更多还原