消渴痹通治疗糖尿病周围神经病变的临床疗效研究

【作者】 张春雨；

【导师】 朴春丽；

【作者基本信息】 长春中医药大学 ， 中医内科学， 2010， 硕士

【摘要】 目的：通过中药治疗糖尿病周围神经病变(diabetic peripheralneu-ropathy DPN)的课题,比较服药前后临床疗效、中医症状、体征改善情况等,以肯定消渴痹通对于糖尿病周围神经病变(diabetic peripheralneu-ropathy DPN)的治疗作用。方法：根据《中药新药临床研究指导原则》的要求,采用随机平行对照,自身前后对照观察的设计方案。采用随机数字表法,将所受试者按就诊顺序编号,区分为治疗组和对照组各30例。两组均予糖尿病基础治疗,对照组给予西药甲钴胺片口服,治疗组在对照组治疗基础上给予消渴痹通口服。对符合诊断标准、纳入标准,经排除标准筛选的入选病例作为受试对象,共计纳入60例。观察症状、体征及临床疗效改善情况,并进行比较。结果：治疗组对于糖尿病周围神经病变的麻木、疼痛、肢体异常感觉明显改善,明显优于对照组；对于患者足背动脉波动、音叉振动觉及血脂均有明显改善。总体疗效结果对比,治疗组总有效率93.33%,对照组总有效率73.33%。两组总有效率比较有显著性差异(P<0.05)。结论：治疗组疗效与对照组相比有显著差异,治疗组显效12例,有效16例,无效2例,总有效率93.33%,对照组显效5例,有效17例,无效8例,总有效率73.3%,两组相比,有显著性差异(P<0.05)。表明消渴痹通在改善临床症状、提高神经传导速度等方面均有良好疗效,且安全性良好。为治疗糖尿病周围神经病变疗效确切的中药研制开发和应用提供了依据,具有明显的优势和广阔的前景,从而提高了中医药对糖尿病周围神经病变的防治和研究水平。更多还原

【Abstract】 Purpose:The use of Chinese medicine treatment of diabetic peripheral neuropathy subjects, For clinical medical record through observation and comparison of clinical efficacy before and after medication and TCM symptoms and signs and other indicators to improve the situation in recognition of Diabetes Bi Tong Tang treatment of diabetic peripheral neuropathy therapeutic effect.Method:According to "Chinese Medicine Clinical Research Drug guiding principles" requirement, randomized parallel-controlled, self-control observation before and after design. Random number table will be the subjects according to treatment sequence number, divided into treatment group and control group 30 cases. The basis of the two groups are therefore correspondingly diabetes treatment and control group was given methylcobalamin tablets western clothes, the treatment group based on the therapy in the control group given oral hypoglycemic Bi-pass. That meet the diagnostic criteria and inclusion criteria, exclusion criteria after screening of the selected cases as the subjects are included in a total of 60 cases. Observe the symptoms to improve the situation, and compared.Result:Treatment group for diabetic peripheral neuropathy numbness, pain, limb paresthesia improved significantly better than the control group; for fluctuations in patients with dorsal artery, tuning fork vibration sense, and lipids were significantly improved. Overall efficacy results compare the efficiency of the treatment group was 93.33% in the control group was 73.33% efficiency. The total effective rate were significantly different (P<0.05).Conclusion:Diabetes Bi Tong and western medicine treatment group compared with the control group were significantly different, the treatment group 12 cases markedly effective in 16 cases and ineffective in 2 cases, the total effective rate 93.33%, control group,5 cases markedly effective in 17 cases,8 cases The total effective rate 73.3%, compared with two groups, there is a significant difference (P<0.05). Show that Bi-pass Diabetes in improving clinical symptoms, improve nerve conduction velocity, etc. have good efficacy, and security was good. For the treatment of diabetic peripheral neuropathy curative effect of Chinese medicine research and development and application provides a basis has obvious advantages and broad prospects, thereby increasing Chinese medicine on diabetes prevention and treatment of peripheral neuropathy, and research level.更多还原