【作者】 王振勇；

【导师】 李勇； 范立侨；

【作者基本信息】 河北医科大学 ， 外科学， 2010， 硕士

【摘要】 胃癌的死亡率在全球癌症死亡率中居第二位,我国胃癌的年死亡率在各种恶性肿瘤中占首位。随着外科手术技术的提高、传统放化疗技术的进步以及新辅助疗法的实施,早期胃癌的5年生存率可达95%以上。然而,大多数胃癌患者确诊时疾病已进入晚期,此时传统的治疗手段都不能有效降低患者的死亡率,应采用包括手术、化疗、放疗及免疫治疗等在内的综合治疗措施。近年来一种新的治疗模式——肿瘤分子靶向治疗在抗肿瘤治疗中发挥着日益重要的作用,并显示出良好的应用前景。这些策略主要包括表皮生长因子受体抑制剂、Her-2受体抑制剂、抗血管生成因子、细胞周期抑制剂、细胞凋亡促进剂等。本文就胃癌的分子靶向治疗进行综述,用于指导进展期胃癌,尤其是不能切除或姑息性切除胃癌患者的治疗,以延长患者的生存期,提高患者的生活质量。更多还原

【Abstract】 Gastric cancer is the second leading cause of cancer mortality worldwide and is a major cause of cancer death in China.Recent improvements in both surgical techniques and adjuvant/neoadjuvant chemotherapy,radiotherapy or both have increased the survival rate of patients with early-stage disease.As most cases of gastric cancer are in the advanced stage of the disease when they are first diagnosed,patients receiving conventional therapies have poor prognosis.An emerging modality called tumor molecular targeted therapy provides promise and insight to combat this malignancy.These therapeutic strategies include epidermal growth factor receptor inhibitors,Her-2 receptor inhibitors,angiogenesis inhibitors,cell cycle inhibitors and apoptosis promoters.This review that presents a brief introduction to molecular targeted therapy of gastric cancer was intended to play a guidance in the therapy of advanced gastric cancer.Its significance is to prolong survival time and improve life quality of patients.更多还原