【作者】 阳懿；

【导师】 孙勇；

【作者基本信息】 泸州医学院 ， 口腔临床医学， 2010， 硕士

【摘要】 目的：通过动物实验,评价无机源性与生物源性骨组织替代材料,在骨缺损再生修复中引导骨组织再生的能力和特点及其差异。方法：对18只兔颅骨骨缺损区采用无机源性与生物源性骨粉填充并用胶原生物膜覆盖通过X线检查、骨组织切片苏木素-伊红染色(HE染色)和Masson三色染色图像分析观察骨缺损区不同实验程期(12、16、24周)的组织修复状况。结果：无机源性与生物源性骨替代材料在兔颅骨的骨缺损修复中,具有良好的生物相容性和引导骨组织再生性和操作性。结论：无机源性与生物源性骨粉均可起到引导新骨再生,完全修复骨缺损的作用。但生物源性骨组织替代材料的成骨性能优于无机源性骨组织替代材料的成骨性能。更多还原

【Abstract】 Objective:The study which was carried through animal experiment evaluated the ability, feature and differences in guiding new bony tissue regeneration of two bony substitutional material inorganic-derived and bio-derived bone in their reparation of bony defects.Methods:Filled the bony defect areas in 18 rabbits’ calvarium with inorganic-derived or bio-derived bone meal and then cover with collagen membrane. The repairing situation is observed and analysed by X-ray, HE and Masson’s trichrome staining on the bone tissue slices at 12,16 and 24 weeks after the operation.Results:Both of inorganic-derived and bio-derived bone meal have biocompatibility, the ability to guid bony tissue regeneration and the possibility to operate in the process of repairing rabbits’ calvarium defects.Conclusion:Both of inorganic-derived and bio-derived bone meal can both guid bony tissue regeneration and completely cover the calvarium defects. And, the bio-derived is better.更多还原