【作者】 陈丽琴；

【导师】 陈霞；

【作者基本信息】 南京中医药大学 ， 中医学， 2010， 硕士

【摘要】 目的：通过临床研究,观察宫腔粘连分离术联合中药补肾化瘀法对人流术后宫腔粘连的疗效,评价中医药治疗对该病的疗效,并对其作用机理进行初步探讨。方法：选择人流术后宫腔粘连患者40例,随机分为两组,治疗组20例,行宫腔粘连分离术后给予补肾活血中药口服；对照组20例,行宫腔粘连分离术后给予克龄蒙口服,治疗3个月经周期。观察两组患者疗效、IUA程度的改善情况及对血清E2、FSH、血液流变学的影响。结果：治疗组经治疗临床总有效率达95%,对照组为80%,治疗组总体疗效优于对照组(P<0.05)。两组患者经治疗中医证候均明显改善(P<0.05),治疗组总有效率达90%,对照组为75%,两组中医证候疗效比较有显著性差异(P<0.05)。治疗组经治疗中医主症总有效率均在80.00%以上,其中经期、经量、月经色质总有效率分别为84.21%、95.00%、94.73%,明显高于对照组(P<0.05)。两组患者经治疗后IUA程度均减轻(P<0.05),但两者无显著性差异(P>0.05)。两组患者经治疗后E2水平明显上升,FSH下降,较疗前均有显著性差异(P<0.05),治疗组和对照组之间无显著性差异(P>0.05)。两组患者经治疗后血液流变学有改善,全血高切、全血低切均较疗前下降(P<0.05),且治疗组优于对照组(P<0.05)。结论：宫腔粘连分离术联合中药补肾化瘀法治疗人流术后宫腔粘连所致月经过少、闭经疗效好,机理可能与调节机体免疫失衡,改善血液高凝状态,防止IUA再形成有关。更多还原

【Abstract】 Objective:Clinical research, observation of transcervical resection of adhesions combined with BuShenHuaYuFang in treating intrauterine adhesion caused by induced abortion, evaluation of the efficacy of medical treatment of the disease and its mechanism were discussed.Methods:The flow of 40 patients with intrauterine adhesion caused by induced abortion were randomly divided into two groups, treatment group 20 cases, were treated with BuShenHuaYuFang after transcervical resection of adhesions; the control group 20 cases, were treated with Climen after transcervical resection of adhesions for three menstrual cycles. To observe treatment efficacy, IUA degree of improvement,affection on sex hormone and hemorheology.Results:The treatment group were treated and total effective rate was 95%,80% in the control group, the overall effect of the treatment group than the control group (P<0.05). The symptoms of two groups were obviously improved (P<0.05), total effective rate of treatment group was 90%,75% in the control group, two groups of Chinese medicine syndromes were significantly different (P<0.05). Chinese medicine treatment group main symptoms after treatment in the 80.00% total effective rate of more than one menstrual period, by volume, color quality of the total effective period were 84.21%,95.00%,94.73%, significantly higher (P<0.05). Two groups after treatment were to reduce the degree IUA(P<0.05), but there was no significant difference (P>0.05). Two groups after treatment significantly increased the level of E2, FSH decreased, compared with before treatment were significantly different (P<0.05), treatment group and control group had no significant difference (P>0.05).Two groups after treatment to improve blood rheology, blood high shear, low shear whole blood compared with pre-treatment decreased (P<0.05), and the treatment group than the control group (P<0.05)Conclusion:Transcervical resection of adhesions combined with BuShenHuaYuFang in treating intrauterine adhesion caused by induced abortion,which effect was significant.The mechanism may be achieved through correcting unbanlanced immunity,improving the blood high viscosity,preventing the reformulation of IUA.更多还原