【作者】 赵宇；

【导师】 李迎新；

【作者基本信息】 天津医科大学 ， 生物医学工程， 2010， 硕士

【摘要】 目的在现有全固态激光模块的基础上,开发针对于眼底病的三波长激光治疗机控制接口和光学接口。控制接口能够进行设备上位机与下位机的通讯,能够控制激光输出模式、功率调节、温度控制。光学接口能够完成激光通过裂隙灯显微镜的传输和光斑的调节。配合课题组其他相关研究完成整体样机设计,使该治疗机适用于多种眼底病,能够更方便地实施因人而异的个性化治疗。方法全固态三波长激光治疗机由半导体激光模块、激光模块驱动、工控机、触摸液晶显示器、直流稳压电源、控制接口电路、光学裂隙灯接口和控制软件系统等组成。系统以红(650nm)、黄(561nm)、绿(532nm)全固态激光光源为基础,以WinCE为系统开发平台,采用EVC4.0编写系统应用软件,通过软硬件的设计与调试,开发电路设计接口。激光控制接口电路是该设计的关键部分,它以ADμC848为核心处理器,接收从工控机传来的控制信号后,输出电流给TEC,控制半导体激光管芯的温度,提供激光模块所需的电流。同时电路还监测激光器工作时的各个关键参数(如实际温度信号、激光管的实际电流信号和电压信号),将信号反馈给工控机,为激光器提供稳定的工作电流和保证其工作在适宜的温度,保证激光器正常运行。当设备中出现异常情况时,启动保护功能,使激光模块不受损并及时报警。系统光学接口以CODE V为平台设计了整套的适用于治疗眼底病变的变焦成像系统,能够进行高效率光纤耦合和光学传输。能够与眼科裂隙灯显微镜与角膜接触镜配合,对病灶进行治疗。结果本文很好地完成了控制接口和光学接口的设计,能够进行单路和多路输出,指示光与激光输出正常,效率高。系统完成的主要功能有：输出通道选择、激光输出功率调节、激光输出时间调节、激光开关控制和病历档案数据库等。用户既可以选择单一通道650nm、561nm、532nm输出,也可以选择多通道同时输出。激光功率可以调节,红光0-1200mW可调,黄光0-1000mW可调,绿光0-2000mW可调。本文完成了具有输出电流负反馈功能、输出光功率自校准功能和TEC自动温控功能的接口电路。开发出适用于临床应用的全固态三波长激光眼底病治疗机的控制软件系统。软件界面良好,能够很好的实现人机交互,输出激光能够准确的通过光纤传导,输出衰减小,能通过裂隙灯准确到达病灶。结论采用全固态多波长控制接口实现了智能化的眼底激光手术系统,可用于眼底病的动物实验,在不同的工作模式下均可安全有效的实施手术。激光器输出连续、稳定,达到了设计要求。系统操控简单,便于临床医生操作。全固态激光器体积小、功率高,一台设备能完成以往多台设备才能完成的工作,使得眼科激光手术不用反复更换激光设备,更加便捷。本系统为激光医疗设备与眼科裂隙灯集成为精度高、稳定性好的全固态多波长激光眼底病治疗设备提供了基础。更多还原

【Abstract】 PurposeDevelope the three wavelength laser machine control interfaces and optical interfaces for the treatment of ocular fundus. The Control interface can communicate between the PC and the under device,.controling the laser output mode, conditioning power, and controling temperature. Optical interface can complete the laser transmission through the slit lamp microscope and the spot regulation. We can complete the overall prototype design with the help of other relevant studies so that the treatment is suitable for varieties of Ophthalmology deseases, which can be implemented to varies personalized treatment more easily.MethodThe Diode-pumped laser tri-wavelength laser Ocular therapy machine is composed of semiconductor laser module, laser module driver, IPC, Touch LCD, DC regulated power supply, control interface circuitry, optical slit lamp interface and software system. The system is based on red (650nm), yellow (561 nm), green (532nm) solid state light source. The circuit design interfaces is developed through hardware and software design and debugging. Laser module drive control interface circuit is the key part of the system. ADμC848 is the core processor, receiving control signal from the IPC, and sending current to the TEC, which controls the temperature of semiconductor module. The control interface circuit provide laser diode (LD) current required, at the same time, monitor the key laser parameters of the whole work, such as the actual temperature signal, the actual laser tube current signal and voltage signal, to ensure normal operation of lasers. The control interface circuit provide laser protection and alarm when abnormal condition accured. The control interface design includes the drive current output circuit, automatic power control circuit, automatic temperature control circuit, a serial interface circuit and the corresponding driver software. The package of zoom imaging system on treatment of retinopathy is designed on the CODE V platform as the System optical interface, which is capable of efficient fiber coupling, and optical transmission. The system fits the contact lens and ophthalmic slit lamp microscopy quite well.ConsultsThe control interface and optical interface is designed, capable of single and multi-output. The indicating light and laser output is normal and high efficiency. The main features are:output channel selection, output power adjustment, output time adjustment, the laser switches and medical records database. Users can either select a single channel 650nm,561nm,532nm. You can also choose multi-channel simultaneous output. Complete the laser module drive circuit controlled by the SCM, which can adjust the output current continuously, adjust the output current feedback, and TEC cooling. Complete the Diode-pumped laser software system, suitable for clinical applications, which achieved the human-computer interaction quite well. The output laser transmit through optical fibers accurately, the output attenuation is small, and get to the focus through the slit lamp accurately.ConclusionThe intelligent retinal laser surgery system using Multi-wavelength Diode-pumped’ laser can be used for ocular fundus of the animal experiments in different working modes. The output power is continuous, stable and meets the design requirements. Diode-pumped laser is small and powerful, and can complete multiple founctions instead of many devices, making eye laser surgery more convenient without repeatedly replacement of laser equipment. The system provides the basis for integration of laser medical equipment and ophthalmic slit lamp.更多还原